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Poly(glycerol sebacate)/Gelatin core/shell fibrous structure for regeneration of Myocardial Infarction.
MedLine Citation:
PMID:  21247338     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Heart failure remains the leading cause of death in many industrialized nations owing to the inability of the myocardial tissue to regenerate. The main objective of this work was to develop a cardiac patch which is biocompatible and matches the mechanical properties of the heart muscle for myocardial infarction. The present study was to fabricate poly (glycerol sebacate)/gelatin (PGS/gelatin) core/shell fibers and gelatin fibers alone by electrospinning for cardiac tissue engineering. PGS/Gelatin core/shell fibers, PGS used as core polymer to impart the mechanical properties and gelatin as a shell material to achieve favourable cell adhesion and proliferation. These core/shell fibers were characterized by SEM, contact angle, FTIR and tensile testing. The cell-scaffold interactions were analyzed by cell proliferation study, confocal analysis for the expression of cardiac specific marker proteins like Actinin, Troponin-T, Platelet Endothelial Cell Adhesion Molecule (PECAM) and SEM to analyze cell morphology. Dual immunofluorescent staining was performed to further confirm the cardiogenic differentiation of MSCs by employing MSC specific marker protein CD 105 and cardiac specific marker protein Actinin. The results observed that PGS/gelatin core/shell fibers, having good potential biocompatibility and mechanical properties for fabricating nanofibrous cardiac patch and would be a prognosticating device for the restoration of myocardium. Keywords: Cardiac patch, poly(glycerol sebacate), gelatin, core/shell fibers, cardiomyocytes, mesenchymal stem cells.
Authors:
Rajeswari Ravichandran; Jayarama Reddy Venugopal; Sundarrajan Subramanian; Shayanti Mukherjee; Seeram Ramakrishna
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-19
Journal Detail:
Title:  Tissue engineering. Part A     Volume:  -     ISSN:  1937-335X     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101466659     Medline TA:  Tissue Eng Part A     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
National University of Singapore, Mechanical Engineering, Healthcare and energy materials laboratory, E3-05-14, 2 Engineering drive 3, Singapore, Singapore, Singapore, 117576, +65 6516 4272; g0900672@nus.edu.sg.
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