Document Detail


Poly(glutamic acid) for biomedical applications.
MedLine Citation:
PMID:  11797908     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Paclitaxel is a widely used anti-cancer agent. Conjugates of paclitaxel with poly(glutamic acid) have shown great promise in preclinical trials, and clinical trials are now underway. Preclinical data suggest that more paclitaxel is preferentially delivered to tumor sites vs. nonconjugated paclitaxel. When poly(glutamic acid) is conjugated to other families of cancer drugs, similar improvements in effectiveness and reduced toxicity are observed. Optimization of poly(glutamic acid) for use in drug delivery applications is a key step in making this technology viable.
Authors:
A Richard; A Margaritis
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Critical reviews in biotechnology     Volume:  21     ISSN:  0738-8551     ISO Abbreviation:  Crit. Rev. Biotechnol.     Publication Date:  2001  
Date Detail:
Created Date:  2002-01-18     Completed Date:  2002-06-25     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8505177     Medline TA:  Crit Rev Biotechnol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  219-32     Citation Subset:  IM    
Affiliation:
Department of Chemical and Biochemical Engineering, The University of Western Ontario, London, Canada.
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MeSH Terms
Descriptor/Qualifier:
Drug Delivery Systems*
Peptide Hydrolases / metabolism
Polyglutamic Acid / administration & dosage*,  biosynthesis,  metabolism
Chemical
Reg. No./Substance:
25513-46-6/Polyglutamic Acid; EC 3.4.-/Peptide Hydrolases; EC 3.4.-/polyglutamyl gamma-hydrolase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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