| Poly(gamma-L-diaminobutanoic acid), a novel poly(amino acid), coproduced with poly(epsilon-L-lysine) by two strains of Streptomyces celluloflavus. | |
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MedLine Citation:
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PMID: 18625024 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two poly(epsilon-L-lysine) (epsilon-PL) producer strains of Streptomyces celluloflavus secreted a novel polymeric substance into their culture broths along with epsilon-PL. Three types of HPLC analysis plus one- and two-dimensional 1H and 13C nuclear magnetic resonance experiments revealed that the secreted substance was poly(gamma-L-diaminobutanoic acid) (gamma-PAB), an L-alpha,gamma-diaminobutanoic acid (L-DAB) homopolymer linking between y-amino and alpha-carboxylic acid functional groups. The gamma-PABs from the two strains had an identical chemical structure, and the same number-average molecular weight of 2100-2200. No copolymers composed of the two amino acids L-DAB and L-lysine were found in either of the broths from the producers. Both strains coproduced high levels of the two poly(amino acid)s in the presence of SO4(2-) at pH 4.0 and 4.5 L min(-1) aeration in a 5-L jar fermentor. gamma-PAB exhibited strong inhibitory activities against various yeasts and weaker actions against bacteria than epsilon-PL. gamma-PAB may have various biological functions similar to epsilon-PL, and the use of gamma-PAB along with epsilon-PL would be advantageous for technical applications in various fields. |
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Authors:
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Munenori Takehara; Masayuki Saimura; Haruka Inaba; Hideo Hirohara |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: FEMS microbiology letters Volume: 286 ISSN: 0378-1097 ISO Abbreviation: FEMS Microbiol. Lett. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-10-29 Completed Date: 2008-11-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7705721 Medline TA: FEMS Microbiol Lett Country: England |
Other Details:
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Languages: eng Pagination: 110-7 Citation Subset: IM |
Affiliation:
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Department of Materials Science, University of Shiga Prefecture, Hikone, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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chemistry*,
metabolism*,
pharmacology Bacteria / drug effects Biopolymers / chemistry, metabolism, pharmacology Fermentation Lysine / chemistry, metabolism Streptomyces / chemistry*, metabolism* Yeasts / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Biopolymers; 56-87-1/Lysine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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