Document Detail


Polyethylene glycol plus simethicone in small-bowel preparation for capsule endoscopy.
MedLine Citation:
PMID:  19736051     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Small-bowel contents can hamper the quality of video-capsule endoscopy (VCE). No standardized protocol has been proposed and overnight fasting remains the proposed preparation for VCE. AIMS: The aim was to evaluate the effects of 2 regimens of bowel preparation on small intestine cleansing, diagnostic yield and capsule transit times. METHODS: This is a prospective, randomized, blinded, and controlled study. Sixty patients referred for VCE were randomized into 2 groups. Group A ingested 2l of a polyethylene glycol and simethicone solution 16h before VCE. Group B were instructed to consume a fibre-free diet and allowed to consume clear liquids the day before VCE. The small-bowel cleansing was graded as "complete" if the entire wall was assessable, "incomplete" if more than 50% of the wall was visible, and "insufficient" if less than 50% of the wall was visible. RESULTS: In group A, a "complete", "incomplete" and "insufficient" small-bowel cleansing was achieved in 42%, 39% and 19% of cases respectively. In group B, a "complete", "incomplete" and "insufficient" small-bowel cleansing was achieved in 43%, 33% and 24% of cases respectively. No significant differences were observed between the two groups, regarding small-bowel cleansing level (p=0.65). No differences were also observed in the diagnostic yield (48.2%, 13.8% and 38% vs 65.5%, 6.9% and 27.6% of positive, suspicious and no findings respectively, in groups A and B [p=0.39]) and small-bowel transit times (mean 288min and 299 min in groups A and B respectively [p=0.70]). CONCLUSIONS: The results of the present study do not support the use of 2l of a polyethylene glycol and simethicone solution before VCE.
Authors:
Cristiano Spada; Maria E Riccioni; Pietro Familiari; Gianluca Spera; Giuseppe A Pirozzi; Michele Marchese; Alessandra Bizzotto; Marcello Ingrosso; Guido Costamagna
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2009-09-06
Journal Detail:
Title:  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver     Volume:  42     ISSN:  1878-3562     ISO Abbreviation:  Dig Liver Dis     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-16     Completed Date:  2010-08-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100958385     Medline TA:  Dig Liver Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  365-70     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Digestive Endoscopy Unit, Università Cattolica del Sacro Cuore, Policlinico Universitario Agostino Gemelli, Largo A. Gemelli, 8, 00168 - Rome, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Capsule Endoscopy*
Cathartics / administration & dosage*
Double-Blind Method
Exophthalmos
Female
Humans
Male
Middle Aged
Polyethylene Glycols / administration & dosage*
Prospective Studies
Simethicone / administration & dosage*
Young Adult
Chemical
Reg. No./Substance:
0/Cathartics; 0/Polyethylene Glycols; 8050-81-5/Simethicone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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