Document Detail

Polyethylene glycol electrolyte solution (Isocolan) for constipation during pregnancy: an observational open-label study.
MedLine Citation:
PMID:  15236717     Owner:  NLM     Status:  MEDLINE    
To evaluate the efficacy of a polyethylene glycol electrolyte solution (PEG-4000) in pregnant women affected by constipation, 40 consecutive pregnant women from 6 to 38 weeks' gestation were enrolled in this preliminary study. Constipation was defined as spontaneous evacuation less than four times a week or the presence of symptoms such as defecation pain, rectal urgency, tenesmus, anal injury, or abdominal pain. A PEG-4000 solution (Isocolan, also marketed in the United States as Golitely/Nulitely) was administered for 15 days at a dose of 250 mL by mouth once or twice a day. The number of bowel movements per week, the presence or absence of liquid stools, tenesmus, urgency, defecation pain, anal lesions, and abdominal pain were evaluated before and after 15 days of treatment. Treatment with PEG-4000 significantly increased the evacuation episodes per week (from 1.66 +/- 0.48 to 3.16 +/- 1.05; P <.01), and constipation was resolved in 27 of 37 women (73%). Defecation pain, anal injury, and abdominal pain significantly improved after PEG-4000 administration. Improvement occurred in both patients with new-onset constipation during pregnancy as well as patients with a history of constipation before pregnancy. These preliminary findings indicate that PEG-4000 may be an effective choice for the treatment of constipation during pregnancy.
Isabella Neri; Immacolata Blasi; Paola Castro; Giuseppe Grandinetti; Alba Ricchi; Fabio Facchinetti
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of midwifery & women's health     Volume:  49     ISSN:  1526-9523     ISO Abbreviation:  J Midwifery Womens Health     Publication Date:    2004 Jul-Aug
Date Detail:
Created Date:  2004-07-06     Completed Date:  2004-09-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100909407     Medline TA:  J Midwifery Womens Health     Country:  United States    
Other Details:
Languages:  eng     Pagination:  355-8     Citation Subset:  IM; N    
Clinica Ostetrica, Modena, Italy.
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MeSH Terms
Constipation / drug therapy*
Defecation / drug effects
Drug Administration Schedule
Electrolytes / administration & dosage*
Gastrointestinal Agents / administration & dosage*
Gastrointestinal Transit / drug effects
Polyethylene Glycols / administration & dosage*
Pregnancy Complications / drug therapy*
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Electrolytes; 0/Gastrointestinal Agents; 0/Golytely; 0/Polyethylene Glycols

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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