Document Detail


Polyethylene glycol addition does not improve exogenous surfactant function in an experimental model of meconium aspiration syndrome.
MedLine Citation:
PMID:  19191106     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Meconium (MEC) is a potent inactivator of pulmonary surfactant. The authors studied the effects of polyethylene glycol addition to the exogenous surfactant over the lung mechanics and volumes. Human meconium was administrated to newborn rabbits. Animals were ventilated for 20 minutes and dynamic compliance, ventilatory pressure, and tidal volume were recorded. Animals were randomized into 3 study groups: MEC group (without surfactant therapy); S100 group (100 mg/kg surfactant); and PEG group (100 mg/kg porcine surfactant plus 5% PEG). After ventilation, a pulmonary pressure-volume curve was built. Histological analysis was carried out to calculate the mean alveolar size (Lm) and the distortion index (DI). Both groups treated with surfactant showed higher values of dynamic pulmonary compliance and lower ventilatory pressure, compared with the MEC group (P < .05). S100 group had a larger maximum lung volume, V(30), compared with the MEC group (P < .05). Lm and DI values were smaller in the groups treated with surfactant than in the MEC group (P < .05). No differences were observed between the S100 and PEG groups. Animals treated with surfactant showed significant improvement in pulmonary function as compared to nontreated animals. PEG added to exogenous surfactant did not improve lung mechanics or volumes.
Authors:
Joao Cesar Lyra; Renata Suman Mascaretti; Alexander Roberto Precioso; Luciana Branco Haddad; Thais Mauad; Flavio A Costa Vaz; Celso Moura Rebello
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental lung research     Volume:  35     ISSN:  1521-0499     ISO Abbreviation:  Exp. Lung Res.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-04     Completed Date:  2009-03-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8004944     Medline TA:  Exp Lung Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  76-88     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, São Paulo State University, Rubiao Junior, Campus Botucatu, Botucatu, Brazil. jc.lyra@uol.com.br
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Disease Models, Animal
Drug Combinations
Humans
Infant, Newborn
Intubation, Intratracheal
Lung / drug effects,  pathology,  physiopathology
Lung Compliance / drug effects,  physiology
Meconium Aspiration Syndrome / drug therapy*,  pathology,  physiopathology
Polyethylene Glycols / pharmacology*
Pulmonary Surfactants / pharmacology*
Rabbits
Respiration, Artificial
Respiratory Mechanics / drug effects*,  physiology
Chemical
Reg. No./Substance:
0/Drug Combinations; 0/Polyethylene Glycols; 0/Pulmonary Surfactants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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