| Polyethylene glycol addition does not improve exogenous surfactant function in an experimental model of meconium aspiration syndrome. | |
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MedLine Citation:
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PMID: 19191106 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Meconium (MEC) is a potent inactivator of pulmonary surfactant. The authors studied the effects of polyethylene glycol addition to the exogenous surfactant over the lung mechanics and volumes. Human meconium was administrated to newborn rabbits. Animals were ventilated for 20 minutes and dynamic compliance, ventilatory pressure, and tidal volume were recorded. Animals were randomized into 3 study groups: MEC group (without surfactant therapy); S100 group (100 mg/kg surfactant); and PEG group (100 mg/kg porcine surfactant plus 5% PEG). After ventilation, a pulmonary pressure-volume curve was built. Histological analysis was carried out to calculate the mean alveolar size (Lm) and the distortion index (DI). Both groups treated with surfactant showed higher values of dynamic pulmonary compliance and lower ventilatory pressure, compared with the MEC group (P < .05). S100 group had a larger maximum lung volume, V(30), compared with the MEC group (P < .05). Lm and DI values were smaller in the groups treated with surfactant than in the MEC group (P < .05). No differences were observed between the S100 and PEG groups. Animals treated with surfactant showed significant improvement in pulmonary function as compared to nontreated animals. PEG added to exogenous surfactant did not improve lung mechanics or volumes. |
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Authors:
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Joao Cesar Lyra; Renata Suman Mascaretti; Alexander Roberto Precioso; Luciana Branco Haddad; Thais Mauad; Flavio A Costa Vaz; Celso Moura Rebello |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Experimental lung research Volume: 35 ISSN: 1521-0499 ISO Abbreviation: Exp. Lung Res. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-02-04 Completed Date: 2009-03-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8004944 Medline TA: Exp Lung Res Country: United States |
Other Details:
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Languages: eng Pagination: 76-88 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, São Paulo State University, Rubiao Junior, Campus Botucatu, Botucatu, Brazil. jc.lyra@uol.com.br |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Disease Models, Animal Drug Combinations Humans Infant, Newborn Intubation, Intratracheal Lung / drug effects, pathology, physiopathology Lung Compliance / drug effects, physiology Meconium Aspiration Syndrome / drug therapy*, pathology, physiopathology Polyethylene Glycols / pharmacology* Pulmonary Surfactants / pharmacology* Rabbits Respiration, Artificial Respiratory Mechanics / drug effects*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Drug Combinations; 0/Polyethylene Glycols; 0/Pulmonary Surfactants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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