| Polyelectrolyte complex nanoparticles of amino poly(glycerol methacrylate)s and insulin. | |
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MedLine Citation:
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PMID: 22197770 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Amino poly(glycerol methacrylate)s (PGOHMAs) were synthesized from linear or star-shaped poly(glycidyl methacrylate)s (PGMA)s via ring opening reactions with 1,2-ethanediamine, 1,4-butanediamine and diethylenetriamine, respectively. The resulting cationic polymers were employed to form polyelectrolyte complexes (PECs) with insulin. Parameters influencing complex formation were investigated by dynamic light scattering (DLS). PECs in the size range of 100-200nm were obtained under optimal conditions, i.e., the pH value of PECs was 5.58-6.27, the concentration of NaCl was 0.02mol/L, and insulin-polymer weight ratio was 0.8. The insulin association efficiency (AE) of current system increased with zeta potentials of PECs. Circular dichroism (CD) analysis corroborated that the structure of insulin in the PEC nanoparticles was preserved after lyophilization. Fourier transform infrared (FT-IR) and X-ray diffraction (XRD) experiments demonstrated that weak physical interactions between insulin and amino PGOHMAs play an important role in the formation of PECs. The release of insulin is depended on both structure and architecture of amino PGOHMAs. These PECs would be potentially useful for mucosal administration. |
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Authors:
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Xueyou Lu; Hui Gao; Cui Li; Ying-Wei Yang; Yinong Wang; Yunge Fan; Guolin Wu; Jianbiao Ma |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-17 |
Journal Detail:
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Title: International journal of pharmaceutics Volume: - ISSN: 1873-3476 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7804127 Medline TA: Int J Pharm Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier B.V. |
Affiliation:
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School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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