| Polyelectrolyte Coated Multilayered Liposomes (Nanocapsules) for the Treatment of Helicobacter pylori Infection. | |
| | |
MedLine Citation:
|
PMID: 19175318 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Helicobacter pylori infection is one of the major causes of gastric cancers. A number of systems have already been reported, but 100% eradication has never been achieved. The present invention designs a gastro-retentive drug delivery system incorporated with amoxicillin and metronidazole, specifically suited for the eradication of Helicobacter pylori infections due to its mucoadhesiveness in the presence of polyelectrolyte polymers. The system possesses the advantages of both vesicular and particulate carriers, and it was prepared by alternative coating of polyanion (poly(acrylic acid), PAA) and polycation (poly(allylamine hydrochloride), PAH) using liposomes as the core. Compared with the conventional liposomes, the polyelectrolyte based multilayered system (nanocapsules) gave prolonged drug release in simulated gastric fluid, which is well suited for drug delivery against H. pylori infection in the stomach. In vitro growth inhibition study, agglutination assay, and in situ adherence assay in cultured H. pylori suggested the successful in vitro activity and binding propensity of the system. In vivo bacterial clearance study carried out in a H. pylori infected mouse model finally confirmed the success of the developed novel nanocapsule system. Thus, the newly developed composite nanocapsules along with the use of combination therapy proved to have commendable potential in Helicobacter pylori eradication as compared to already existing conventional and novel drug delivery systems. |
| | |
Authors:
|
Parul Jain; Sanyog Jain; K N Prasad; S K Jain; Suresh P Vyas |
Related Documents
:
|
11713948 - Paradoxical role of helicobacter pylori infection: protective effect against ethanol-in... 10452678 - Relationship between helicobacter pylori infection and histologic features of gastritis... 8563048 - Histological responses to helicobacter pylori infection: gastritis, atrophy and preneop... 12144568 - Review article: helicobacter pylori infection and gastric outlet obstruction - prevalen... 1841208 - The development of leishmania infantum in phlebotomus langeroni nitzulescu (diptera: ps... 13383368 - Q fever in domestic and wild birds. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2009-1-28 |
Journal Detail:
|
Title: Molecular pharmaceutics Volume: - ISSN: 1543-8392 ISO Abbreviation: Mol. Pharm. Publication Date: 2009 Jan |
Date Detail:
|
Created Date: 2009-2-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101197791 Medline TA: Mol Pharm Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar (M.P.) 470003, India, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Sector 67, SAS Nagar (Mohali), Punjab 160062, India, and Department of Microbiology, Sanjay Gandhi P.G. Institute of Medial Sciences, Lucknow (U.P.), India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of mutation of carboxyl side-chain amino acids near the heme on the midpoint potentials and l...
Next Document: Novel indazole non-nucleoside reverse transcriptase inhibitors using molecular hybridization based o...