Document Detail

Polydrug use, cannabis, and psychosis-like symptoms.
MedLine Citation:
PMID:  18449850     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine psychosis-like symptoms in users of legal and illicit drugs. METHODS: Schizotypal Personality Questionnaire (SPQ) scores were compared in groups of people with different exposure to cannabis, with the use of other drugs serving as a covariate. Supplemental analyses compared users of legal and illicit drugs with cannabis use as a covariate. RESULTS: Weekly (n = 111) and monthly (n = 136) cannabis users had higher scores on the SPQ than former (n = 143) and non-users (n = 81). The use of other drugs accounted for the links between cannabis and schizotypy. Lifetime use of psychomotor stimulant drugs plus ecstasy accounted for associations between cannabis and scores on the SPQ and its different subscales. Dividing groups by type of drug use revealed that those who used only cannabis and legal drugs (CLDs) (n = 126) were no different from those who used only legal drugs (LDs) (n = 74) but both groups scored significantly lower on the SPQ than polydrug users (n = 247). When controlling for marijuana use in the last month, the significant difference across drug use groups remained. CONCLUSIONS: The results suggest that research on marijuana and schizotypy requires careful assessment of the use of other drugs, especially psychomotor stimulants and ecstasy.
Nicholas T Van Dam; Mitch Earleywine; Greg DiGiacomo
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human psychopharmacology     Volume:  23     ISSN:  1099-1077     ISO Abbreviation:  Hum Psychopharmacol     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-07     Completed Date:  2008-11-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8702539     Medline TA:  Hum Psychopharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  475-85     Citation Subset:  IM    
Copyright Information:
(c) 2008 John Wiley & Sons, Ltd.
Department of Psychology, University at Albany, SUNY, Albany, New York 12222, USA.
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MeSH Terms
Central Nervous System Stimulants / adverse effects
Cognition / drug effects
Marijuana Abuse / complications*
N-Methyl-3,4-methylenedioxyamphetamine / adverse effects
Psychoses, Substance-Induced / etiology*
Schizotypal Personality Disorder / chemically induced*
Reg. No./Substance:
0/Central Nervous System Stimulants; 42542-10-9/N-Methyl-3,4-methylenedioxyamphetamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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