| Polydisulfide manganese(II) complexes as non-gadolinium biodegradable macromolecular MRI contrast agents. | |
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MedLine Citation:
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PMID: 22031457 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: To develop safe and effective manganese(II) -based biodegradable macromolecular MRI contrast agents. MATERIALS AND METHODS: In this study, we synthesized and characterized two polydisulfide manganese(II) complexes, Mn-DTPA cystamine copolymers and Mn-EDTA cystamine copolymers, as new biodegradable macromolecular MRI contrast agents. The contrast enhancement of the two manganese-based contrast agents were evaluated in mice bearing MDA-MB-231 human breast carcinoma xenografts, in comparison with MnCl(2) . RESULTS: The T(1) and T(2) relaxivities were 4.74 and 10.38 mM(-1) s(-1) per manganese at 3T for Mn-DTPA cystamine copolymers (M(n) = 30.50 kDa) and 6.41 and 9.72 mM(-1) s(-1) for Mn-EDTA cystamine copolymers (M(n) = 61.80 kDa). Both polydisulfide Mn(II) complexes showed significant liver, myocardium and tumor enhancement. CONCLUSION: The manganese-based polydisulfide contrast agents have a potential to be developed as alternative non-gadolinium contrast agents for MR cancer and myocardium imaging. J. Magn. Reson. Imaging 2011;. © 2011 Wiley Periodicals, Inc. |
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Authors:
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Zhen Ye; Eun-Kee Jeong; Xueming Wu; Mingqian Tan; Shouyu Yin; Zheng-Rong Lu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-26 |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: - ISSN: 1522-2586 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
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Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA; Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah, USA. |
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