Document Detail


Polydipsia in rhesus monkeys deficient in omega-3 fatty acids.
MedLine Citation:
PMID:  2159161     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Omega-3 fatty acids are a major component of neural membranes. They are essential nutrients for normal biochemical development of the brain and retina and may affect behavior. In our studies of long-term dietary omega-3 fatty acid deficiency, we have found a new effect of this deficiency in rhesus monkeys. Deficient monkeys visited the home cage drinking spout more frequently than controls (Experiment 1), and drank more water over 24 hours (Experiment 2). The increase in intake was mirrored by increased combined output of urine + feces over 24 hours (Experiment 3), and was not due to spillage (Experiment 4). The dietary deficiency greatly reduced omega-3 fatty acids in red blood cells but did not affect serum electrolyte levels. The changes in fluid intake and output may be related to direct or indirect effects on central or peripheral control mechanisms for drinking or excretion, which may be mediated by altered composition of neural or other membranes or changes in eicosanoid metabolism.
Authors:
S Reisbick; M Neuringer; R Hasnain; W E Connor
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Physiology & behavior     Volume:  47     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-06-05     Completed Date:  1990-06-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  315-23     Citation Subset:  IM    
Affiliation:
Department of Medicine, Oregon Health Sciences University, Portland 97201.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cerebral Cortex / physiology
Drinking / physiology*
Fatty Acids, Omega-3 / administration & dosage*
Female
Macaca mulatta
Nutritional Requirements
Retina / physiology
Synaptic Transmission / physiology
Visual Perception / physiology
Water-Electrolyte Balance / physiology
Grant Support
ID/Acronym/Agency:
DK-29930/DK/NIDDK NIH HHS; HL-07295/HL/NHLBI NIH HHS; RR-00163/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids, Omega-3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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