| Polydipsia in rhesus monkeys deficient in omega-3 fatty acids. | |
| | |
MedLine Citation:
|
PMID: 2159161 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Omega-3 fatty acids are a major component of neural membranes. They are essential nutrients for normal biochemical development of the brain and retina and may affect behavior. In our studies of long-term dietary omega-3 fatty acid deficiency, we have found a new effect of this deficiency in rhesus monkeys. Deficient monkeys visited the home cage drinking spout more frequently than controls (Experiment 1), and drank more water over 24 hours (Experiment 2). The increase in intake was mirrored by increased combined output of urine + feces over 24 hours (Experiment 3), and was not due to spillage (Experiment 4). The dietary deficiency greatly reduced omega-3 fatty acids in red blood cells but did not affect serum electrolyte levels. The changes in fluid intake and output may be related to direct or indirect effects on central or peripheral control mechanisms for drinking or excretion, which may be mediated by altered composition of neural or other membranes or changes in eicosanoid metabolism. |
| | |
Authors:
|
S Reisbick; M Neuringer; R Hasnain; W E Connor |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Physiology & behavior Volume: 47 ISSN: 0031-9384 ISO Abbreviation: Physiol. Behav. Publication Date: 1990 Feb |
Date Detail:
|
Created Date: 1990-06-05 Completed Date: 1990-06-05 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 315-23 Citation Subset: IM |
Affiliation:
|
Department of Medicine, Oregon Health Sciences University, Portland 97201. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cerebral Cortex / physiology Drinking / physiology* Fatty Acids, Omega-3 / administration & dosage* Female Macaca mulatta Nutritional Requirements Retina / physiology Synaptic Transmission / physiology Visual Perception / physiology Water-Electrolyte Balance / physiology |
| Grant Support | |
ID/Acronym/Agency:
|
DK-29930/DK/NIDDK NIH HHS; HL-07295/HL/NHLBI NIH HHS; RR-00163/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Fatty Acids, Omega-3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Copulatory thrusting pattern in the male rat after acute treatment with GABA transaminase inhibitors...
Next Document: Insulin stimulates inositol incorporation in hippocampus of lean but not obese Zucker rats.