| Polydextrose induces precocious cessation of intestinal macromolecular transmission and development of digestive enzymes in the suckling rat. | |
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MedLine Citation:
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PMID: 7614040 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of repeated oral administration of polydextrose and pectin on intestinal macromolecular transport and digestive enzymes development was examined in the suckling rat. The administration of polydextrose for 7 days resulted in pancreatic hyperplasia, followed by the enhancement of trypsin activity. The length of the small intestine and the wet weight of the cecum were significantly increased by polydextrose treatment. Maltase activity was increased in a dose dependent manner by polydextrose, but not by pectin treatment. Lactase activity was not changed by either treatment. The absorption of bovine IgG was precociously depressed by polydextrose, but not by pectin treatment. These results suggest that oral administration of polydextrose induces precocious maturation of the small intestine and exocrine pancreas in the suckling rat. |
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Authors:
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E Harada; Y Hashimoto; B Syuto |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Comparative biochemistry and physiology. Part A, Physiology Volume: 111 ISSN: 1096-4940 ISO Abbreviation: Comp. Biochem. Physiol. A Physiol. Publication Date: 1995 Jul |
Date Detail:
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Created Date: 1995-08-22 Completed Date: 1995-08-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9516062 Medline TA: Comp Biochem Physiol A Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 479-85 Citation Subset: IM |
Affiliation:
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Department of Veterinary Physiology, Faculty of Agriculture, Tottori University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Suckling Body Weight / physiology DNA / metabolism Dietary Fiber* Digestion / drug effects, physiology* Disaccharidases / metabolism Food Additives / pharmacology* Glucans / pharmacology* Immunoglobulin G / metabolism Intestine, Small / enzymology, metabolism Intestines / drug effects, growth & development*, metabolism* Paraffin Embedding Pectins / pharmacology Proteins / metabolism Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Food Additives; 0/Glucans; 0/Immunoglobulin G; 0/Pectins; 0/Proteins; 68424-04-4/polydextrose; 9007-49-2/DNA; EC 3.2.1.-/Disaccharidases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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