Document Detail


Polydactyly Nagoya, Pdn: A new mutant gene in the mouse.
MedLine Citation:
PMID:  7202526     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new hereditary polydactyly (gene symbol Pdn) was found in the course of breeding JCL : ICR mice. The genetic analysis indicated that the polydactyly was an autosomal dominant trait. The homozygotes died within two days after birth. The homozygous fetuses or newborn had 1-3 extra-digits both in te fore- and hindlimbs on the preaxial side. They occasionally showed exencephaly, cleft palate, open eyelid, short tibia and fibula or deformed sternum. The heterozygotes had one extra-digit preaxial side. They occasionally showed exencephaly, heterozygotes had one extra-digit preaxially in the hindlimb and an enlarged first digit on the forelimb which often showed bifurcated distal phalanx. A tab on the postaxial side of the forelimb was found in all homozygotes and in some heterozygotes.
Authors:
I Hayasaka; T Nakatsuka; T Fujii; I Naruse; S Oda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Jikken dobutsu. Experimental animals     Volume:  29     ISSN:  0007-5124     ISO Abbreviation:  Jikken Dobutsu     Publication Date:  1980 Oct 
Date Detail:
Created Date:  1981-05-21     Completed Date:  1981-05-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1256412     Medline TA:  Jikken Dobutsu     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  391-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Forelimb / abnormalities
Genes, Dominant*
Heterozygote
Hindlimb / abnormalities
Homozygote
Male
Mice*
Mutation*
Rodent Diseases / genetics*
Toes / abnormalities*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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