Document Detail

Polycythemia vera in an anephric man.
MedLine Citation:
PMID:  1015515     Owner:  NLM     Status:  MEDLINE    
The effect of renal failure and bilateral nephrectomy on erythropoiesis and plasma erythropoietic activity was observed in a patient with polycythemia vera. For eight years the patient's hematocrit was maintained between 45 and 50 per cent by phlebotomy and in spite of the development of renal failure the hematocrit did not decline. Following rejection of a renal transplant, the hematocrit fell to 18 per cent but rose to 40 per cent with oral iron therapy. Following bilateral nephrectomy, the hematocrit fell to 29 per cent but subsequently increased to 37 per cent. After an episode of gastrointestinal bleeding the hematocrit was 21 per cent but subsequently rose to 32 per cent. Erythropoietin could not be detected in the plasma either before or after nephrectomy. In addition, erythropoietin failed to stimulate 59Fe incorporation into heme in vitro in the patient's marrow cells. The data incidate that, in polycythemia vera, erythropoiesis does not require erythropoietin.
J L Spivak; C R Cooke
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  272     ISSN:  0002-9629     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:    1976 Nov-Dec
Date Detail:
Created Date:  1977-03-15     Completed Date:  1977-03-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  339-44     Citation Subset:  AIM; IM    
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MeSH Terms
Bone Marrow / metabolism
Bone Marrow Cells
Erythropoietin / blood
Heme / metabolism
Kidney Failure, Chronic / surgery
Middle Aged
Polycythemia Vera / blood,  metabolism,  physiopathology*
Reg. No./Substance:
11096-26-7/Erythropoietin; 14875-96-8/Heme

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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