Document Detail

Polycythemia produced in rats by environmental contaminants.
MedLine Citation:
PMID:  475469     Owner:  NLM     Status:  MEDLINE    
Polycythemia developed in progeny from mothers who were exposed during pregnancy to a combination of methylmercury chloride plus ethylurea and sodium nitrite. The polycythemia occurred as early as one month of age and as many as 24% of the offspring developed the polycythemic condition. Many features of this condition are similar to those of polycythemia vera in man, such as elevated hematocrits and white and red blood cell counts, splenomegaly, and hyperplasia of bone marrow accompanied by megakaryocytosis.
L D Koller; J H Exon; J E Nixon
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of environmental health     Volume:  34     ISSN:  0003-9896     ISO Abbreviation:  Arch. Environ. Health     Publication Date:    1979 Jul-Aug
Date Detail:
Created Date:  1979-10-24     Completed Date:  1979-10-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0212627     Medline TA:  Arch Environ Health     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  252-5     Citation Subset:  AIM; IM    
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MeSH Terms
Environmental Pollutants*
Heart / anatomy & histology
Organ Size / drug effects
Organomercury Compounds*
Polycythemia / chemically induced*
Spleen / anatomy & histology
Urea / analogs & derivatives*
Reg. No./Substance:
0/Environmental Pollutants; 0/Nitrites; 0/Organomercury Compounds; 57-13-6/Urea

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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