Document Detail


Polycythemia in an infant secondary to granulocyte transfusions.
MedLine Citation:
PMID:  21370438     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Granulocyte transfusions may be useful for neutropenic pediatric patients with refractory bacterial or fungal infections. Many potential adverse sequelae associated with granulocyte transfusions are well recognized, including febrile reactions, fluid overload, alloimmunization, and lung injury. Other potential adverse sequelae, however, are less well known. This case report describes an infant with familial hemophagocytic lymphohistiocytosis who developed polycythemia (hemoglobin 10-17.6 g/dl) following four daily transfusions of 20 ml/kg of apheresis collected, steroid stimulated donor granulocytes. Expanded knowledge of potential risks of transfused granulocytes will allow for rapid recognition of transfusion-related complications, should they occur.
Authors:
Olufolake Adisa; Jeanne E Hendrickson; Courtney K Hopkins; Howard M Katzenstein; Cassandra D Josephson
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural     Date:  2011-03-02
Journal Detail:
Title:  Pediatric blood & cancer     Volume:  57     ISSN:  1545-5017     ISO Abbreviation:  Pediatr Blood Cancer     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-18     Completed Date:  2012-01-03     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  101186624     Medline TA:  Pediatr Blood Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1236-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Female
Granulocytes / transplantation*
Humans
Infant
Infection / etiology
Leukocyte Transfusion / adverse effects*
Lymphohistiocytosis, Hemophagocytic / complications,  therapy*
Polycythemia / etiology*
Grant Support
ID/Acronym/Agency:
HL-07-001/HL/NHLBI NIH HHS; K07 HL088922/HL/NHLBI NIH HHS; K07 HL088922-04/HL/NHLBI NIH HHS
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