Document Detail

Polycystins under pressure.
MedLine Citation:
PMID:  19879836     Owner:  NLM     Status:  MEDLINE    
All cells detect mechanical signals, but the underlying molecular mechanisms are unclear. In this issue of Cell, Sharif-Naeini et al. (2009) show that a candidate mechanosensing channel, TRPP2 (PKD2), unexpectedly acts as an inhibitor of a still-elusive stretch-activated cation channel in vascular smooth muscle cells.
Bernd Nilius
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Cell     Volume:  139     ISSN:  1097-4172     ISO Abbreviation:  Cell     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-11-02     Completed Date:  2009-12-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  466-7     Citation Subset:  IM    
KU Leuven, Department of Molecular Cell Biology, Laboratory Ion Channel Research, B-3000 Leuven, Belgium.
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MeSH Terms
Muscle, Smooth, Vascular / physiology*
Myocytes, Smooth Muscle
TRPP Cation Channels / chemistry,  physiology*
Reg. No./Substance:
0/TRPP Cation Channels; 0/polycystic kidney disease 2 protein
Comment On:
Cell. 2009 Oct 30;139(3):587-96   [PMID:  19879844 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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