Document Detail

Polycystic ovary syndrome: infertility, cardiovascular, metabolic and obstetrical risks, laboratory and clinical outcomes-The PICOLO Study.
MedLine Citation:
PMID:  22217188     Owner:  NLM     Status:  Publisher    
Objectives: The primary objective of this multicenter study is to evaluate the relative impact of insulin resistance (IR) and body mass index (BMI) in women with polycystic ovary syndrome (PCOS) on (1) Key hemodynamic/thrombogenic variables, (2) Oocyte quality and early embryo development, (3) Fetal growth, placental function and adverse obstetric outcome. Secondary objective: To establish a PCOS database and biobank facilitating future basic and interventional research related to PCOS. Design: A cross-sectional and longitudinal cohort study at four University Hospitals in Denmark. Population inclusion: About 200 women fulfilling the Rotterdam Criteria and 100 women without PCOS recruited from 2010 to 2012. Methods: The impact of PCOS, as well as the impact of IR and BMI on the hormonal, metabolic and hemostatic key variables will be analyzed combining conventional, molecular techniques and selected gene analysis. Oocytes will be characterized by gene expression of granulosa and cumulus cells and the early embryo development will be followed by time lapse microscopy. Fetal growth will be assessed by repeated ultrasound measurements, and the pregnancy outcome compared to maternal and fetal biochemical markers of growth and inflammation and clinical pregnancy complications. Main outcome measures: Metabolic and hemostatic risk-biomarkers, oocyte and embryo quality, adverse pregnancy outcome, fetal growth and placental function in women with PCOS.
M Aziz; Kv Naver; Mlm Wissing; Al Mikkelsen; L Nilas; So Skouby
Related Documents :
24559658 - Birth defects and assisted reproductive technologies.
23682598 - Impact of risk factors on hypertensive disorders in pregnancy, in primiparae and multip...
19675518 - Meigs' syndrome and virilizing ovarian fibrothecoma complicating pregnancy. a case repo...
898638 - Clinical examinations of the ovaries and cervix of the sow.
23746798 - Fetal growth in women with homozygous sickle cell disease: an observational study.
1742388 - Coffee consumption, birthweight, and reproductive failures.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-4
Journal Detail:
Title:  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology     Volume:  -     ISSN:  1473-0766     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807913     Medline TA:  Gynecol Endocrinol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Gynecology and Obstetrics, Herlev University Hospital , Denmark.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Photochemistry of Riboflavin Derivatives in Methanolic Solutions.
Next Document:  Abnormal End-Tidal Carbon Dioxide Levels on Emergency Department Arrival in Adult and Pediatric Intu...