Document Detail


Polycystic ovary syndrome in bulimic women--an evaluation based on the new diagnostic criteria.
MedLine Citation:
PMID:  16864149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An association between bulimia nervosa and polycystic ovary syndrome (PCOS) has been suggested but also questioned. Since there is still a controversy about this issue, we investigated clinical and biochemical symptoms of PCOS according to the new diagnostic criteria in a large group of bulimic women compared with controls. Seventy-seven women with bulimia and 59 matched healthy women were investigated with respect to menstrual status, polycystic ovaries, hirsutism, acne and sex hormone levels. We found increased occurrence of menstrual disturbances, hirsutism and PCOS in bulimic women, whereas ovarian variables and acne did not differ from controls. Hirsutism score and indices of biologically active testosterone were positively correlated in bulimics but not in controls, while there were no major differences in serum androgens. In conclusion, this study supports an increased frequency of PCOS in bulimic women and may also indicate increased androgen sensitivity in these women. PCOS may promote bulimic behavior since androgens have appetite-stimulating effects and could impair impulse control. Menstrual disturbances and clinical signs of hyperandrogenism should be evaluated in bulimics in order to provide adequate medical care and treatment.
Authors:
Sabine Naessén; Kjell Carlström; Leena Garoff; Rolf Glant; Angelica Lindén Hirschberg
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology     Volume:  22     ISSN:  0951-3590     ISO Abbreviation:  Gynecol. Endocrinol.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-25     Completed Date:  2007-01-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807913     Medline TA:  Gynecol Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  388-94     Citation Subset:  IM    
Affiliation:
Department of Women and Child Health, Division of Obstetrics and Gynecology, Karolinska University Hospital, Stockholm, Sweden. Sabine.Naessén@karolinska.se
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MeSH Terms
Descriptor/Qualifier:
Adult
Bulimia / complications*,  diagnosis*
Case-Control Studies
Dehydroepiandrosterone / blood
Female
Follicle Stimulating Hormone / blood
Gonadal Steroid Hormones / blood
Hirsutism / diagnosis
Humans
Luteinizing Hormone / blood
Menstruation Disturbances / diagnosis
Oligomenorrhea / diagnosis
Polycystic Ovary Syndrome / complications*,  diagnosis*
Sex Hormone-Binding Globulin / analysis
Chemical
Reg. No./Substance:
0/Gonadal Steroid Hormones; 0/Sex Hormone-Binding Globulin; 53-43-0/Dehydroepiandrosterone; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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