Document Detail

Polycystic kidney disease in the first year of life.
MedLine Citation:
PMID:  3668738     Owner:  NLM     Status:  MEDLINE    
To determine the frequency of autosomal recessive and autosomal dominant polycystic kidney disease (PKD) in infants and to compare the rate of progression of these conditions, we conducted a retrospective survey of 48 patients who were seen with PKD before 1 year of age and who survived the first month of age. Seventeen patients had recessive PKD; six had dominant PKD. Eighteen patients had insufficient data to categorize the type of PKD with certainty. Seven patients were classified as "other"; three had glomerulocystic disease and the remainder had multiple malformation syndromes or tuberous sclerosis. Renal ultrasonography and excretory urography accurately detected 15 of 17 patients with recessive PKD, but only one patient with dominant PKD was correctly diagnosed by excretory urography. The majority of patients in all groups required antihypertensive therapy. The 17 children with recessive PKD have been followed up for 6.1 +/- 4.3 (SD) years. Eight patients are doing well. Two patients have died; five others have required treatment for renal failure. Only one patient has an estimated glomerular filtration rate within the normal range after 6 years of age. Long-term evaluation of most of the patients with dominant PKD is not yet available; however, by age 42 months one patient has required dialysis. To provide optimum genetic counseling and accurate diagnosis for patients with PKD, a combination of careful family evaluation, radiography, and liver or kidney biopsy is required. The outcome of patients who survive the neonatal period appears not to be so grim as previously feared, underscoring the importance of aggressive supportive care and the need for physician and family education.
B R Cole; S B Conley; F B Stapleton
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  111     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1987-12-14     Completed Date:  1987-12-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  693-9     Citation Subset:  AIM; IM    
Southwest Pediatric Nephrology Study Group, Washington University School of Medicine, St. Louis.
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MeSH Terms
Age Factors
Antihypertensive Agents / therapeutic use
Child, Preschool
Diagnosis, Differential
Genes, Dominant
Genes, Recessive
Hypertension, Renal / drug therapy,  etiology
Infant, Newborn
Polycystic Kidney Diseases / diagnosis,  epidemiology*,  genetics
Renal Dialysis
Retrospective Studies
Reg. No./Substance:
0/Antihypertensive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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