Document Detail


Polycyclic xanthone natural products: structure, biological activity and chemical synthesis.
MedLine Citation:
PMID:  23334431     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Polycyclic xanthone natural products are a family of polyketides which are characterized by highly oxygenated, angular hexacyclic frameworks. In the last decade, this novel class of molecules has attracted noticeable attention from the synthetic and biological communities due to emerging reports of their potential use as antitumour agents. The aim of this article is to highlight the most recent developments of this subset of the xanthone family by detailing the innate challenges of the construction of this class of natural products, new synthetic approaches, and pharmacological data.
Authors:
Dana K Winter; David L Sloman; John A Porco
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-21
Journal Detail:
Title:  Natural product reports     Volume:  30     ISSN:  1460-4752     ISO Abbreviation:  Nat Prod Rep     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-14     Completed Date:  2013-04-26     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  8502408     Medline TA:  Nat Prod Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  382-91     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents* / chemical synthesis,  chemistry,  pharmacology
Biological Products* / chemical synthesis,  chemistry,  pharmacology
Molecular Structure
Polycyclic Compounds / chemical synthesis,  chemistry,  pharmacology
Xanthones* / chemical synthesis,  chemistry,  pharmacology
Grant Support
ID/Acronym/Agency:
R01 CA137270/CA/NCI NIH HHS; R01 CA137270/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Biological Products; 0/Polycyclic Compounds; 0/Xanthones
Comments/Corrections

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