| Polycyclic aromatic hydrocarbons potentiate high-fat diet effects on intestinal inflammation. | |
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MedLine Citation:
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PMID: 20412841 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We demonstrate that intestinal inflammation caused by high-fat diet is increased by the environmental contaminant benzo[a]pyrene. Our in vivo results indicate that a high-fat diet (HFD) induces a pre-diabetic state in mice compared with animals fed normal chow. HFD increased IL-1betamRNA concentration in the jejunum, colon, and liver, and TNFalpha was increased in the colon and strongly increased in the liver. HFD also increased the expression of other genes related to type 2 diabetes, such as the uncoupling protein UCP2, throughout the bowel and liver, but not in the colon. The treatment of HFD with BaP enhanced the expression of IL-1beta in the liver and TNFalpha throughout the bowel and in the liver. Adding BaP to the diet also caused a significant decrease in the expression of the incretin glucagon-like peptide 1, which plays an important role in insulin secretion. Our results suggest that intestinal inflammation may be involved in the onset of type 2 diabetes and that chronic exposure to environmental polycyclic aromatic hydrocarbons can increase the risk of type 2 diabetes by inducing pro-inflammatory cytokine production. |
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Authors:
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Ayman Khalil; Pierre-Henri Villard; Mai Anh Dao; R?my Burcelin; Serge Champion; Francis Fouchier; Jean-Francois Savouret; Yves Barra; Eric Seree |
Publication Detail:
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Type: Journal Article Date: 2010-04-20 |
Journal Detail:
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Title: Toxicology letters Volume: 196 ISSN: 1879-3169 ISO Abbreviation: Toxicol. Lett. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-10 Completed Date: 2010-06-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7709027 Medline TA: Toxicol Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 161-7 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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INRA, UMR1260 Nutriments Lipidiques et Pr?vention des Maladies M?taboliques, Universit? de la M?diterran?e, Marseille F-13385, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Benzo(a)pyrene / toxicity* Diabetes Mellitus, Type 2 / etiology* Dietary Fats / toxicity* Enteritis / etiology* Glucagon-Like Peptide 1 / analysis Insulin / blood Interleukin-10 / analysis Interleukin-1beta / genetics Ion Channels / genetics Male Mice Mice, Inbred C57BL Mitochondrial Proteins / genetics Tumor Necrosis Factor-alpha / genetics Weight Gain / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Interleukin-1beta; 0/Ion Channels; 0/Mitochondrial Proteins; 0/Tumor Necrosis Factor-alpha; 0/mitochondrial uncoupling protein 2; 11061-68-0/Insulin; 130068-27-8/Interleukin-10; 50-32-8/Benzo(a)pyrene; 89750-14-1/Glucagon-Like Peptide 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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