| Polycyclic aromatic hydrocarbon-deoxyribonucleic acid (PAH-DNA) adduct levels and exposure to coke oven emissions among workers in Taiwan. | |
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MedLine Citation:
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PMID: 14738276 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study, the authors evaluated the relationship between polycyclic aromatic hydrocarbon-deoxyribonucleic acid (PAH-DNA) adduct levels in workers' peripheral white blood cells (WBCs) and their occupational exposures to coke oven emissions (measured by air and urinary 1-hydroxypyrene [1-OHP]). Personal exposures to smoking, charbroiled food, changing clothes in the workplace, and respirator use were determined by questionnaire. Eighty-nine coke oven workers were divided into 3 exposure groups on the basis of job description: topside workers, cokeside workers, and plant office staff. Referent subjects comprised 63 individuals from the same company who worked at a site remote from the coking plant. The geometric mean (GM) PAH-DNA adduct levels determined from the WBCs of the exposed groups were 6.86, 1.56, and 0.90 adducts/10(8) nucleotides, respectively (referents = 0.38 adducts/10(8) nucleotides). GM personal benzene soluble fraction (BSF) exposures for the exposed groups were 483.2 microg/m3, 70.1 microg/m3, and 43.2 microg/m3, respectively (referents = 10.7 microg/m3). There was a significant correlation (p < 0.05) between individual BSF and PAH-DNA adduct levels for the exposed groups. The authors also found a significant correlation (p < 0.05) between urinary 1-OHP levels from the day 2 samples of the exposed groups and their PAH-DNA adduct levels. The logistic-regression model revealed that PAH-DNA adduct levels were significantly different between job categories. The results of this study indicate that BSF exposure is the primary contributor to PAH-DNA adduct levels determined from WBCs. |
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Authors:
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Mei-Lien Chen; Bing-Chi Lee; Pei-Ling Lu; I-Fang Mao; Tsung-Yun Liu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of environmental health Volume: 58 ISSN: 0003-9896 ISO Abbreviation: Arch. Environ. Health Publication Date: 2003 May |
Date Detail:
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Created Date: 2004-01-23 Completed Date: 2004-02-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0212627 Medline TA: Arch Environ Health Country: United States |
Other Details:
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Languages: eng Pagination: 298-305 Citation Subset: AIM; IM |
Affiliation:
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Institute of Environmental Health Sciences, College of Medicine, National Yang-Ming University, Taipei, Taiwan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Air Pollution, Indoor / adverse effects* Coke* DNA Adducts* Humans Incineration Industry Inhalation Exposure* Leukocytes Male Middle Aged Occupational Exposure* Polycyclic Hydrocarbons, Aromatic / poisoning* Regression Analysis Taiwan |
| Chemical | |
Reg. No./Substance:
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0/Coke; 0/DNA Adducts; 0/Polycyclic Hydrocarbons, Aromatic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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