| Polycyclic aromatic hydrocarbon-DNA adducts in spontaneously aborted fetal tissue. | |
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MedLine Citation:
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PMID: 2401055 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fetal tissue and placentas from 15 human spontaneous abortions were evaluated for DNA adducts of polycyclic aromatic hydrocarbons (PAHs), using a competitive enzyme-linked immunosorbent assay (ELISA) with fluorescent end-point detection. PAH-derived adducts were found in 43% of placentas, 27% of fetal liver samples and 42% of fetal lung specimens, thus confirming that the human fetus is a target for DNA damage. As there was only 60% concordance between placenta and fetal lung or liver on the presence or absence of detectable PAH adducts, the placenta was not a good surrogate for adduct formation in other fetal organs. PAH-derived adducts in fetal liver and lung presumably form as a result of transplacental exposure to environmental stimuli. Since none of the positive fetal samples were from women who reported smoking during pregnancy, cigarette smoke is, in this case, an unlikely candidate and the adducts detected must be due to some other common source(s) of hydrocarbon exposure. The high frequency of positive samples in our small series casts some doubt on whether fetal PAH-DNA adducts identify a population at increased risk for transplacental carcinogenesis. |
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Authors:
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M C Hatch; D Warburton; R M Santella |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Carcinogenesis Volume: 11 ISSN: 0143-3334 ISO Abbreviation: Carcinogenesis Publication Date: 1990 Sep |
Date Detail:
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Created Date: 1990-10-26 Completed Date: 1990-10-26 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8008055 Medline TA: Carcinogenesis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1673-5 Citation Subset: IM |
Affiliation:
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Division of Epidemiology, Columbia University School of Public Health, New York, NY 10032. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous* Carcinogens / analysis* DNA / analysis* Enzyme-Linked Immunosorbent Assay Female Fetus / analysis* Gestational Age Humans Liver / analysis Lung / analysis Placenta / analysis* Polycyclic Compounds / analysis* Pregnancy |
| Grant Support | |
ID/Acronym/Agency:
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OHO 2622/OH/NIOSH CDC HHS; P01 CA 21111/CA/NCI NIH HHS; R01 HD 15909/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens; 0/Polycyclic Compounds; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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