Document Detail


Polycyclic Aromatic Hydrocarbon Residues in Human Milk, Placenta and Umbilical Cord Blood in Beijing, China.
MedLine Citation:
PMID:  22032748     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This paper provides the results of an investigation on dietary intakes and internal doses of polycyclic aromatic hydrocarbons (PAHs) for non-smoking women from Beijing, China. Concentrations of PAHs were measured using GC/MS for human milk, placenta, and umbilical cord blood samples from 40 non-smoking women and for 144 composite food samples covering major food categories. Information on food consumptions and estimated ingestion doses of PAHs by the cohort was also collected individually. Relationship among the studied human samples and relative importance of breastfeeding to the total exposure dose of infants were addressed. The median (mean and standard deviation) total concentrations of 15 PAHs in human milk, placenta, and umbilical cord blood with (or without) fat normalization were 278 (9.305.75), 819 (35.915.4), and 1370 (5.5213.71) ng/gfat (ng/g), respectively, and the corresponding levels of benzo(a)pyrene equivalent (B[a]Peq) were 11.2 (0.4730.605), 16.2 (0.7170.318), and 13.1 (0.1400.225) ng/g•fat (ng/g), respectively. The calculated intake of B[a]Peq by Beijing cohort varied from 0.609 to 4.69 ng/kgd with a median value of 1.93 (2.09±0.921 as mean ± standard deviation) ng/kgd. Significant correlations were found among human milk, placenta, and umbilical cord blood (p < 0.05) for low-molecular-weight PAHs, indicating selective transfer potential of individual PAHs from mother to fetus. Internal dose of PAHs was not in proportion to amounts of food ingestion, daily dietary intake, lifestyle, and social-demographic characteristics of the participants (p > 0.05). Ingested doses of PAHs (3.00-102 ng/kgd), which were much higher than the inhaled doses (0.152-8.50 ng/kgd), were 3-4 orders of magnitude lower than the recommended reference doses, unlikely imposing any obvious risk based on current knowledge.
Authors:
Yanxin Yu; Xilong Wang; Bin Wang; Shu Tao; Wen-Xin Liu; Xuejun Wang; Jun Cao; Bengang Li; Xiaoxia Lu; M H Wong
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-27
Journal Detail:
Title:  Environmental science & technology     Volume:  -     ISSN:  1520-5851     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0213155     Medline TA:  Environ Sci Technol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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