Document Detail


Polycomb group protein-mediated repression of transcription.
MedLine Citation:
PMID:  20346678     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The polycomb group (PcG) proteins are essential for the normal development of multicellular organisms. They form multi-protein complexes that work as transcriptional repressors of several thousand genes controlling differentiation pathways during development. How the PcG proteins work as transcriptional repressors is incompletely understood, but involves post-translational modifications of histones by two major PcG protein complexes: polycomb repressive complex 1 and polycomb repressive complex 2.
Authors:
Lluís Morey; Kristian Helin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-03-24
Journal Detail:
Title:  Trends in biochemical sciences     Volume:  35     ISSN:  0968-0004     ISO Abbreviation:  Trends Biochem. Sci.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-23     Completed Date:  2010-08-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7610674     Medline TA:  Trends Biochem Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  323-32     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Animals
Histones / metabolism
Humans
Repressor Proteins / metabolism*
Response Elements
Transcription Factors / metabolism
Transcription, Genetic*
Chemical
Reg. No./Substance:
0/Histones; 0/Repressor Proteins; 0/Transcription Factors; 0/polycomb group proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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