| Polyclonal cytomegalovirus-specific antibodies not only prevent virus dissemination from the portal of entry but also inhibit focal virus spread within target tissues. | |
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MedLine Citation:
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PMID: 18365251 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Therapy of cytomegalovirus (CMV) infection in recipients of hematopoietic stem cell transplantation (HSCT) by immune serum transfer did not fulfill the high clinical expectations, although immune sera or immunoglobulin-enriched preparations pooled from many CMV-immune donors are likely to contain virus neutralizing antibodies covering a broad range of virus variants. Likewise, the highest risk of CMV disease in HSCT recipients results from the reactivation of the latently infected recipient's own virus despite pre-transplantation humoral immunity. These findings suggest the conclusion that antiviral antibodies are inefficient in controlling CMV. Rather than B cells and antibodies, T cells, in particular CD8 T cells, are thought to play a major role in resolving established organ infection. In theory, antibodies, though being capable of neutralizing free virions, could fail to prevent cell-bound virus dissemination from the portal of entry to distant target tissues and also could fail in preventing cell-to-cell spread within tissue. Here we have used murine model systems, including B cell deficient C57BL/6 micro(- ) micro(-) (microMT) mutants, to revisit the role of antiviral antibodies in the control of CMV infection and to reevaluate the prospects of an antibody-based immunotherapy from a basic science point of view. |
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Authors:
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Nikolaus Wirtz; Sina I Schader; Rafaela Holtappels; Christian O Simon; Niels A W Lemmermann; Matthias J Reddehase; Jürgen Podlech |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-03-26 |
Journal Detail:
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Title: Medical microbiology and immunology Volume: 197 ISSN: 0300-8584 ISO Abbreviation: Med. Microbiol. Immunol. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-04-16 Completed Date: 2008-09-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0314524 Medline TA: Med Microbiol Immunol Country: Germany |
Other Details:
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Languages: eng Pagination: 151-8 Citation Subset: IM |
Affiliation:
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Institute for Virology, Johannes Gutenberg-University, Obere Zahlbacher Strasse 67, Hochhaus am Augustusplatz, 55131 Mainz, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Viral / immunology* B-Lymphocytes / immunology Cytomegalovirus / immunology* Immunocompromised Host Liver / immunology, virology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Neutralization Tests |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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