Document Detail

Polychlorinated biphenyls, dibenzofurans, and quaterphenyls in the toxic rice-bran oil and PCBs in the blood of patients with PCB poisoning in Taiwan.
MedLine Citation:
PMID:  6425849     Owner:  NLM     Status:  MEDLINE    
A mass outbreak of poisoning occurred in central Taiwan in 1979 due to the ingestion of rice-bran oil contaminated with polychlorinated biphenyls (PCBs). In addition to PCBs, polychlorinated dibenzofurans ( PCDFs ) and polychlorinated quaterphenyls ( PCQs ) were also found in the contaminated oil. The levels of toxic agents in the rice-oil samples collected from factory and school cafeterias and the families of the intoxicated patients were in the range of 53-99 ppm, 0.18-0.40 ppm, and 25-53 ppm for PCBs, PCDFs , and PCQs , respectively. Major components of PCBs and PCDFs in the toxic oil were separated and identified by gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS) using glass capillary columns. The most toxic PCB reported in commercial PCB preparations, 3,4,3'-4'-tetrachlorobiphenyl, was found in the toxic oil as well as in one of the patients' blood and adipose tissue at an early stage of poisoning. The blood samples of 165 patients collected 9 to 18 months after the onset of poisoning contained 10 to 720 ppb of PCBs with a mean value of 38 ppb. One of the most toxic PCDFs , 2,3,4,7,8-pentachlorodibenzofuran, was retained in the liver of a deceased patient. This compound could play an important role in the etiology of PCB poisoning in Taiwan.
P H Chen; M L Luo; C K Wong; C J Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Progress in clinical and biological research     Volume:  137     ISSN:  0361-7742     ISO Abbreviation:  Prog. Clin. Biol. Res.     Publication Date:  1984  
Date Detail:
Created Date:  1984-06-18     Completed Date:  1984-06-18     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7605701     Medline TA:  Prog Clin Biol Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  133-45     Citation Subset:  IM    
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MeSH Terms
Adipose Tissue / analysis
Benzofurans / analysis,  poisoning*
Chlorobenzenes / analysis,  poisoning*
Food Contamination*
Foodborne Diseases / etiology*
Gas Chromatography-Mass Spectrometry
Liver / analysis
Oils / analysis,  poisoning*
Oryza sativa*
Polychlorinated Biphenyls / analysis,  blood,  poisoning*
Reg. No./Substance:
0/Benzofurans; 0/Chlorobenzenes; 0/Oils; 0/Polychlorinated Biphenyls; 0/chlorinated dibenzofurans; 0/polychlorinated quaterphenyls

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