| Polycarboxylic acid nanoparticles for ophthalmic drug delivery: an ex vivo evaluation with human cornea. | |
| | |
MedLine Citation:
|
PMID: 15799540 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In ophthalmic drug delivery, a major problem is retaining an adequate concentration of a therapeutic agent in the pre-corneal area. Polycarboxylic acid carriers such as polyacrylic acid and polyitaconic acid in sub-colloidal, nanoparticulate hydrogel form have a strong potential for sustained release of a drug in ocular delivery. Formulations have been prepared of brimonidine loaded in polycarboxylic (polyacrylic and polyitaconic) acid nanoparticles for potential ophthalmic delivery. These particles were prepared by a reverse micro-emulsion polymerization technique with sizes in the range of 50 nm. The loading efficiencies of the drug brimonidine in the particles were shown to be between 80-85% for polyacrylic acid nanoparticles and between 65-70% for polyitaconic nanoparticles. The loading efficiency was also found to be pH dependent. In a preliminary biocompatibility test, human corneal epithelial cells incubated with polyacrylic acid nanoparticles were found to retain their viability, whereas polyitaconic acid nanoparticles were found to be toxic. Two-photon laser scanning microscopic studies of the fluorescently labelled polyacrylic acid nanoparticles and human cornea shows that they are adhesive on the corneal surface. The polyacrylic acid nanoparticles demonstrated a controlled release of the opthalmological drug (Brimonidine) through the human cornea as compared to that of the commercial formulation, Alphagan. |
| | |
Authors:
|
T K De; E J Bergey; S J Chung; D J Rodman; D J Bharali; P N Prasad |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: Journal of microencapsulation Volume: 21 ISSN: 0265-2048 ISO Abbreviation: J Microencapsul Publication Date: 2004 Dec |
Date Detail:
|
Created Date: 2005-03-31 Completed Date: 2005-06-09 Revised Date: 2009-07-21 |
Medline Journal Info:
|
Nlm Unique ID: 8500513 Medline TA: J Microencapsul Country: England |
Other Details:
|
Languages: eng Pagination: 841-55 Citation Subset: IM |
Affiliation:
|
Institute for Lasers, Photonics and Biophotonics, Department of Chemistry, SUNY at Buffalo, Buffalo, NY 14260, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acrylates
/
chemistry,
pharmacokinetics Antihypertensive Agents / chemistry, pharmacokinetics* Carboxylic Acids Cells, Cultured Delayed-Action Preparations Drug Compounding / methods Epithelial Cells / drug effects, metabolism Epithelium, Corneal / drug effects*, metabolism Humans Hydrogels Hydrogen-Ion Concentration Microscopy, Confocal Microscopy, Electron, Transmission Nanostructures Nanotechnology Polymers Quinoxalines / chemistry, pharmacokinetics* Succinates / chemistry, pharmacokinetics |
| Chemical | |
Reg. No./Substance:
|
0/Acrylates; 0/Antihypertensive Agents; 0/Carboxylic Acids; 0/Delayed-Action Preparations; 0/Hydrogels; 0/Polymers; 0/Quinoxalines; 0/Succinates; 59803-98-4/brimonidine; 79-10-7/acrylic acid; 97-65-4/itaconic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Alginate microparticles for Polymyxin B Peyer's patches uptake: microparticles for antibiotic oral a...
Next Document: Formulation and characterization of triclosan sub-micron emulsions and nanocapsules.