| Poly(butyl methacrylate-co-methacrylic acid) tissue engineering scaffold with pro-angiogenic potential in vivo. | |
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MedLine Citation:
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PMID: 17530634 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A poly(butyl methacrylate-co-methacrylic acid) (BMA-MAA) scaffold was fabricated by an in situ polymerization solvent casting/particulate leaching technique. It displayed high porosity (85-90%), pore interconnectivity, and a pore size range of 100-650 microm. Compression testing of the scaffolds demonstrated a dependence of the compressive stiffness on several fabrication variables including the ratio of monomer to salt used during the polymerization, the degree of salt fusion, and the choice of alternative comonomers to BMA. Subcutaneous implantation of BMA-MAA scaffolds in mice revealed an increased level of histological angiogenesis in tissue invading the pores of the scaffold compared to a BMA control, consistent with the prediction that methacrylic acid (MAA) containing copolymer beads are angiogenic in a wound healing context. At postoperative day 21, the capillary density in the BMA-MAA scaffolds was 56 +/- 13/mm(2) as compared to 32 +/- 8/mm(2) for the BMA scaffolds. With further investigation, it is expected that this biomaterial capable of eliciting an angiogenic response will have widespread application in tissue engineering. |
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Authors:
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Mark J Butler; Michael V Sefton |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of biomedical materials research. Part A Volume: 82 ISSN: 1549-3296 ISO Abbreviation: - Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-06-20 Completed Date: 2007-08-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101234237 Medline TA: J Biomed Mater Res A Country: United States |
Other Details:
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Languages: eng Pagination: 265-73 Citation Subset: IM |
Affiliation:
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Department of Chemical Engineering and Applied Chemistry, Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biocompatible Materials / chemistry* Compressive Strength Male Materials Testing Methacrylates / chemistry* Mice Microcirculation / growth & development Microscopy, Electron, Scanning Neovascularization, Physiologic* Polymethacrylic Acids / chemistry* Prostheses and Implants Tissue Engineering* |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Methacrylates; 0/Polymethacrylic Acids; 0/poly(butyl methacrylate) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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