Document Detail

Polybrominated diphenyl ethers and organochlorine pesticides in human breast milk from Massachusetts, USA.
MedLine Citation:
PMID:  17968447     Owner:  NLM     Status:  MEDLINE    
Concentrations of polybrominated diphenyl ethers (PBDEs), and organochlorine pesticides (OCPs; DDTs, HCHs, CHLs, and HCB) were measured in human breast milk samples collected across Massachusetts, USA, in 2004. Seventeen PBDE congeners were found in the samples, ranging in concentration from 0.06 to 1910 ng g(-1) lipid wt. BDE-47 (2,2',4,4'-tetraBDE), BDE-99 (2,2',4,4',5-pentaBDE), and BDE-100 (2,2',4,4',6-pentaBDE) were the major congeners detected in breast milk samples. Overall mean (+/-SD) concentrations of DDTs, HCHs, CHLs, and HCB were 64.5 +/- 75, 18.9 +/- 19, 32.4 +/- 36, and 2.3 +/- 2.2 ng g(-1) lipid wt, respectively. Concentrations of PBDEs were strongly correlated with concentrations of OCPs in the samples. Based on the concentrations of organohalogens and the intake rates of breast milk by infants in the United States, daily ingestion rates of contaminants were calculated. The median ingestion rates for PBDEs, HCHs, DDTs, CHLs, and HCB were 4.0, 212, 141, 44, and 5.79 ng kg(-1) body wt day(-1), respectively. The estimated daily intake of organohalogens by infants was compared with threshold reference values suggested by the United States Environmental Protection Agency (USEPA) and the Agency for Toxic Substances and Disease Registry (ATSDR), for calculation of hazard quotients (HQs). HQs for individual organohalogens and the sum of HQ for all organohalogens were calculated as HQ indices (HQI). The results suggest that one or more of the contaminants analyzed in this study exceeded the threshold reference values in at least 26% of the breast milk samples.
Boris Johnson-Restrepo; Rudolf Addink; Chung Wong; Kathleen Arcaro; Kurunthachalam Kannan
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2007-08-10
Journal Detail:
Title:  Journal of environmental monitoring : JEM     Volume:  9     ISSN:  1464-0325     ISO Abbreviation:  J Environ Monit     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-30     Completed Date:  2008-03-11     Revised Date:  2008-03-12    
Medline Journal Info:
Nlm Unique ID:  100968688     Medline TA:  J Environ Monit     Country:  England    
Other Details:
Languages:  eng     Pagination:  1205-12     Citation Subset:  IM    
Wadsworth Center, New York State Department of Health, School of Public Health, State University of New York at Albany, Empire State Plaza, PO Box 509, Albany, NY 12201-0509, USA.
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MeSH Terms
Environmental Exposure
Gas Chromatography-Mass Spectrometry
Hydrocarbons, Chlorinated / analysis*
Infant, Newborn
Middle Aged
Milk, Human / chemistry*
Pesticides / analysis*
Polybrominated Biphenyls / analysis*
Quality Control
United States
United States Environmental Protection Agency
Grant Support
CCU223392//PHS HHS
Reg. No./Substance:
0/Hydrocarbons, Chlorinated; 0/Pesticides; 0/Polybrominated Biphenyls
Erratum In:
J Environ Monit. 2007 Dec;9(12):1430

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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