| Polybioside, a neuroactive compound from the venom of the social wasp Polybia paulista. | |
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MedLine Citation:
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PMID: 20158240 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Polybioside (1) was isolated from the venom of the social wasp Polybia paulista, and its structure was assigned as 3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl 3-(1H-imidazol-4-yl)propanimidate by NMR and MS protocols. The application of polybioside in rat brain, followed by the detection of c-Fos protein expression in some brain regions, indicated the compound is neuroactive in a number of brain areas. Polybioside causes convulsions in rats, even when peripherally applied. |
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Authors:
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Daniel M Saidemberg; Luiz C da Silva-Filho; Lilian M M Cesar Tognoli; Claudio F Tormena; Mario S Palma |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of natural products Volume: 73 ISSN: 1520-6025 ISO Abbreviation: J. Nat. Prod. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-23 Completed Date: 2010-06-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7906882 Medline TA: J Nat Prod Country: United States |
Other Details:
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Languages: eng Pagination: 527-31 Citation Subset: IM |
Affiliation:
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Laboratory of Structural Biology and Zoochemistry, Department of Biology/CEIS, Institute of Biosciences, S?o Paulo State University (UNESP), 13506-900, Rio Claro, SP, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / cytology, drug effects Brazil Central Nervous System Agents / chemistry, isolation & purification*, pharmacology* Glucosides / chemistry, isolation & purification*, pharmacology* Imidazoles / chemistry, isolation & purification*, pharmacology* Male Molecular Structure Neurons / drug effects Nuclear Magnetic Resonance, Biomolecular Proto-Oncogene Proteins c-fos / drug effects, metabolism Rats Rats, Wistar Seizures / chemically induced Wasp Venoms / chemistry* Wasps / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Central Nervous System Agents; 0/Glucosides; 0/Imidazoles; 0/Proto-Oncogene Proteins c-fos; 0/Wasp Venoms; 0/polybioside |
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