Document Detail


Polyarticular gout attacks following cerebrovascular accidents: is hemiparesis in fact protective? 2 cases and a review of the literature.
MedLine Citation:
PMID:  20689442     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cerebrovascular disease appears to have implications on rheumatic diseases, including gout. Accumulating evidence suggests that hemiparesis exerts a protective effect against gout via the down-regulation of mechanical and neural modulators of inflammation in neurologically impaired extremities. We present 2 divergent cases of unilateral gout following cerebrovascular events. One patient with a hemorrhagic stroke developed polyarticular gout only on the ipsilateral side to his hemiparesis, while another patient with basilar artery thrombosis and locked-in syndrome suffered a polyarticular gout flare only on the side that had regained limited function. As suggested by these cases, the effect of hemiparesis on gout is complex. Further insight into the interplay between gouty flares and hemiparesis may lead to novel therapeutic strategies for gout.
Authors:
Susan J Hsiao; Maksim Vaynrub; Victoria Furer; Jonathan Samuels
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases     Volume:  16     ISSN:  1536-7355     ISO Abbreviation:  J Clin Rheumatol     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-02     Completed Date:  2010-12-16     Revised Date:  2014-02-24    
Medline Journal Info:
Nlm Unique ID:  9518034     Medline TA:  J Clin Rheumatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  293-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Central Nervous System / physiopathology
Gout / diagnosis,  etiology*,  metabolism
Humans
Male
Middle Aged
Paresis / complications*,  physiopathology
Rheumatic Diseases / prevention & control*
Stroke / complications*,  physiopathology
Thrombosis / complications*,  physiopathology
Uric Acid / metabolism
Grant Support
ID/Acronym/Agency:
T32 GM007308/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
268B43MJ25/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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