| Polyarticular gout attacks following cerebrovascular accidents: is hemiparesis in fact protective? 2 cases and a review of the literature. | |
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MedLine Citation:
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PMID: 20689442 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cerebrovascular disease appears to have implications on rheumatic diseases, including gout. Accumulating evidence suggests that hemiparesis exerts a protective effect against gout via the down-regulation of mechanical and neural modulators of inflammation in neurologically impaired extremities. We present 2 divergent cases of unilateral gout following cerebrovascular events. One patient with a hemorrhagic stroke developed polyarticular gout only on the ipsilateral side to his hemiparesis, while another patient with basilar artery thrombosis and locked-in syndrome suffered a polyarticular gout flare only on the side that had regained limited function. As suggested by these cases, the effect of hemiparesis on gout is complex. Further insight into the interplay between gouty flares and hemiparesis may lead to novel therapeutic strategies for gout. |
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Authors:
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Susan J Hsiao; Maksim Vaynrub; Victoria Furer; Jonathan Samuels |
Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases Volume: 16 ISSN: 1536-7355 ISO Abbreviation: J Clin Rheumatol Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-02 Completed Date: 2010-12-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9518034 Medline TA: J Clin Rheumatol Country: United States |
Other Details:
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Languages: eng Pagination: 293-4 Citation Subset: IM |
Affiliation:
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New York University School of Medicine, New York University Langone Medical Center, New York, NY, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Central Nervous System
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physiopathology Gout / diagnosis, etiology*, metabolism Humans Male Middle Aged Paresis / complications*, physiopathology Rheumatic Diseases / prevention & control* Stroke / complications*, physiopathology Thrombosis / complications*, physiopathology Uric Acid / metabolism |
| Chemical | |
Reg. No./Substance:
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69-93-2/Uric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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