| Polyarthritis flare complicating rheumatoid arthritis infliximab therapy: a paradoxic adverse reaction. | |
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MedLine Citation:
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PMID: 17149054 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The treatment of rheumatoid arthritis (RA) has changed dramatically over the past decade with the introduction of antitumor necrosis factor (anti-TNF) agents. Although subsets of patients may have only partial or no response, there is no report yet on possible worsening of RA with this therapy. OBJECTIVE: The objective of this study was to determine whether infliximab may paradoxically exacerbate RA. METHODS: One hundred seven patients with RA refractory to 3 disease-modifying antirheumatic drugs were treated with 3 mg/kg infliximab and methotrexate for at least 6 months. RESULTS: In 3 patients, there was an exacerbation of RA associated with the use of infliximab. The flare occurred during the first 6 to 12 months of treatment with polyarthritis, fever, and elevated acute phase reactants. Increase of infliximab dose resulted in further deterioration. CONCLUSION: We describe a paradoxic reaction, an exacerbation of RA, with infliximab. The mechanism of this side effect is unclear but may be related to altered immunity induced by the inhibition of TNF activity in predisposed patients. |
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Authors:
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Michael Rozenbaum; Nina Boulman; Gleb Slobodin; Elena Ayubkhanov; Itzhak Rosner |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases Volume: 12 ISSN: 1076-1608 ISO Abbreviation: J Clin Rheumatol Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-12-06 Completed Date: 2007-02-28 Revised Date: 2008-04-10 |
Medline Journal Info:
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Nlm Unique ID: 9518034 Medline TA: J Clin Rheumatol Country: United States |
Other Details:
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Languages: eng Pagination: 269-71 Citation Subset: IM |
Affiliation:
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Department of Rheumatology, Bnai Zion Medical Center, Haifa, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antibodies, Monoclonal / adverse effects*, therapeutic use* Arthritis, Rheumatoid / classification, drug therapy*, pathology* Female Humans Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/infliximab |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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