| Poly(amino acid)s: promising enzymatically degradable stealth coatings for liposomes. | |
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MedLine Citation:
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PMID: 17145145 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Poly(amino acid)s (PAAs) were evaluated as coating polymers for long-circulating liposomes. The pharmacokinetics of PAA-coated liposomes were assessed in rats. Prolonged circulation times were obtained, comparable to those reported for poly(ethylene glycol) (PEG)-liposomes. Besides, the enzymatic degradability of PAAs was studied. PAAs - in free as well as liposome-associated form - are degradable by proteases, which is beneficial for reducing the risks of accumulation in vivo. Furthermore, complement activation by PAA-liposomes was evaluated in vitro and in vivo. Like other liposome types, they appear to activate the complement system. However, a role of endotoxin contamination of the PAA-liposome formulations used cannot be excluded in our complement activation studies. |
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Authors:
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Birgit Romberg; Josbert M Metselaar; Lajos Baranyi; Cor J Snel; Rolf Bünger; Wim E Hennink; Janos Szebeni; Gert Storm |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-11-11 |
Journal Detail:
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Title: International journal of pharmaceutics Volume: 331 ISSN: 0378-5173 ISO Abbreviation: Int J Pharm Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-02-13 Completed Date: 2007-04-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7804127 Medline TA: Int J Pharm Country: Netherlands |
Other Details:
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Languages: eng Pagination: 186-9 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands. B.Romberg@pharm.uu.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coated Materials, Biocompatible / chemistry*, metabolism, pharmacokinetics Complement Activation / drug effects Drug Carriers / chemistry*, metabolism, pharmacokinetics Injections, Intravenous Liposomes / chemistry*, metabolism, pharmacokinetics Male Nylons / chemistry, metabolism, pharmacokinetics* Peptide Hydrolases / metabolism Pharmacokinetics Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Coated Materials, Biocompatible; 0/Drug Carriers; 0/Liposomes; 0/Nylons; EC 3.4.-/Peptide Hydrolases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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