Document Detail

Poly(amino acid) functionalized maghemite and gold nanoparticles.
MedLine Citation:
PMID:  23358466     Owner:  NLM     Status:  Publisher    
Bimodal MRI/OI imaging probes are of great interest in nanomedicine. Although many organic polymers have been studied thoroughly for in vivo applications, reports on the use of poly(amino acid)s as coating polymers are scarce. In this paper, poly-(d-glutamic acid, d-lysine) (PGL) has been used for coating maghemite and gold nanoparticles. An advantage of this flexible and biocompatible polymer is that, once anchored to the nanoparticle surface, dangling lysine amino groups are available for the incorporation of new functionalities. As an example, Alexa Fluor derivatives have been attached to PGL-coated maghemite nanoparticles to obtain magnetic/fluorescent materials. These dual-property materials could be used as bimodal MRI/OI probes for in vivo imaging.
Davide Perego; Norberto Masciocchi; Antonietta Guagliardi; José Manuel Domínguez-Vera; Natividad Gálvez
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-28
Journal Detail:
Title:  Nanotechnology     Volume:  24     ISSN:  1361-6528     ISO Abbreviation:  Nanotechnology     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101241272     Medline TA:  Nanotechnology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  075102     Citation Subset:  -    
Departamento de Química Inorgánica, Facultad de Ciencias, Universidad de Granada, E-18071 Granada, Spain. Dipartimento di Scienza e Alta Tecnologia and CNISM, Università dell'Insubria, via Valleggio 11, I-22100 Como, Italy.
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