Document Detail


Poly[(amino acid ester)phosphazenes] as substrates for the controlled release of small molecules.
MedLine Citation:
PMID:  7948574     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Three different poly[(amino acid ester)phosphazenes] have been examined in order to investigate their possible use as drug delivery vehicles. The three polymers are poly[di(ethyl glycinato)phosphazene], poly[di(ethyl alanato)phosphazene] and poly[di(benzyl alanato)phosphazene]. These macromolecules either share the same amino acid residue or the same ester group, and this facilitated comparisons of the hydrolytic decomposition and the small molecule release profiles of the polymers. The polymers were synthesized by treatment of poly(dichlorophosphazene) with an excess of the appropriate amino acid ester. Tetrahydrofuran solutions of each polymer were then thoroughly mixed with ethacrynic acid, a diuretic, or Biebrich Scarlet, an azo dye. Films cast from these solutions were immersed in aqueous media (pH 7) at 25 degrees C and at 37 degrees C for approximately 1400 h. During these experiments, the release of the small molecules was monitored by UV/visible spectroscopy. The molecular weight decline and the mass loss of the polyphosphazene films were measured.
Authors:
H R Allcock; S R Pucher; A G Scopelianos
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biomaterials     Volume:  15     ISSN:  0142-9612     ISO Abbreviation:  Biomaterials     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-12-06     Completed Date:  1994-12-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100316     Medline TA:  Biomaterials     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  563-9     Citation Subset:  IM    
Affiliation:
Department of Chemistry, Pennsylvania State University, University Park 16802.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / chemistry*
Biodegradation, Environmental
Delayed-Action Preparations*
Esters
Ethacrynic Acid / chemistry
Hydrolysis
Organophosphorus Compounds / chemical synthesis,  chemistry*
Particle Size
Polymers / chemical synthesis,  chemistry*
Spectrophotometry, Ultraviolet
Structure-Activity Relationship
Substrate Specificity
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Delayed-Action Preparations; 0/Esters; 0/Organophosphorus Compounds; 0/Polymers; 58-54-8/Ethacrynic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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