Document Detail

Polyamines and diamine oxidase activity in maternal, embryonal, and fetal tissues of rat after chronic ethanol consumption.
MedLine Citation:
PMID:  3103615     Owner:  NLM     Status:  MEDLINE    
The effects of maternal ethanol consumption for 4 weeks before and throughout gestation on polyamine content and diamine oxidase activity of maternal, embryonal and fetal tissues are reported. At the 12th day of pregnancy, a decrease of putrescine in the liver of the mother and marked increases in putrescine, cadaverine and spermidine in embryos were observed. At day 18, putrescine and cadaverine diminished in maternal liver and placenta, and no changes in amine content in fetal liver and brain were found. At day 12, diamine oxidase activity increased in maternal liver and placenta, whereas it greatly diminished in embryos. At day 18, enzyme activity decreased in maternal liver, placenta, fetal liver and brain. These results indicate that chronic ethanol ingestion induces alterations in polyamine concentrations and metabolism in growing and developing tissues during pregnancy that might contribute to the adverse effect of ethanol on conceptual development.
M A Desiderio; A Sessa; A Perin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  142     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-04-01     Completed Date:  1987-04-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  843-8     Citation Subset:  IM    
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MeSH Terms
Amine Oxidase (Copper-Containing) / metabolism*
Brain / drug effects,  embryology,  metabolism
Cadaverine / metabolism
Embryo, Mammalian / drug effects,  metabolism*
Ethanol / pharmacology*
Fetus / drug effects,  metabolism*
Liver / drug effects,  embryology,  metabolism
Maternal-Fetal Exchange
Placenta / drug effects,  metabolism
Polyamines / metabolism*
Putrescine / metabolism
Spermidine / metabolism
Reg. No./Substance:
0/Polyamines; 110-60-1/Putrescine; 124-20-9/Spermidine; 462-94-2/Cadaverine; 64-17-5/Ethanol; EC Oxidase (Copper-Containing)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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