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Polyamines Are Implicated in the Emergence of the Embryo from Obligate Diapause.
MedLine Citation:
PMID:  21303959     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Embryonic diapause is a poorly understood phenomenon of reversible arrest of embryo development prior to implantation. In many carnivores, such as the mink (Neovison vison), obligate diapause characterizes each gestation. Embryo reactivation is controlled by the uterus by mechanisms that remain elusive. Because polyamines are essential regulators of cell proliferation and growth, it was hypothesized that they trigger embryo reactivation. To test this, mated mink females were treated with α-difluoromethylornithine, an inhibitor of ornithine decarboxylase 1, the rate-limiting enzyme in polyamine biosynthesis, or saline as a control during the first 5 d of reactivation. This treatment induced polyamine deprivation with the consequence of rearrest in embryo cell proliferation. A mink trophoblast cell line in vitro subjected to α-difluoromethylornithine treatment likewise displayed an arrest in cell proliferation, morphological changes, and intracellular translocation of ornithine decarboxylase 1 protein. The arrest in embryo development deferred implantation for a period consistent with the length of treatment. Successful implantation and parturition ensued. We conclude that polyamine deprivation brought about a reversible rearrest of embryo development, which returned the mink embryo to diapause and induced a second delay in embryo implantation. The results are the first demonstration of a factor essential to reactivation of embryos in obligate diapause.
Authors:
Pavine L C Lefèvre; Marie-France Palin; Gary Chen; Gustavo Turecki; Bruce D Murphy
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-8
Journal Detail:
Title:  Endocrinology     Volume:  -     ISSN:  1945-7170     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Centre de Recherche en Reproduction Animale (P.L.C.L., B.D.M.), Faculté de Médecine Vétérinaire, Université de Montréal, Québec, Canada J2S 7C6; Dairy and Swine Research and Development Centre (M.-F.P.), Agriculture and Agri-Food Canada, Québec, Canada J1M 1Z3; and Department of Psychiatry (G.C., G.T.), McGill Group for Suicide Studies, Douglas Hospital, Québec, Canada H4H 1R3.
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