| Polyamine oxidation, programmed cell death, and regulation of melanoma in the murine embryonic limb. | |
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MedLine Citation:
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PMID: 2510929 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The murine embryonic limb at day 14 of gestation suppresses tumor formation by melanoma cells. Conditioned media of embryonic limbs have been found cytotoxic for B16 melanoma cells. The cytotoxicity is due to the catabolism of polyamines in the limb bud extracts by an amine oxidase in the serum supplement of the culture medium. However, a polyamine oxidase activity, similar to that in adult rat liver, is also detectable in homogenates of embryonic limbs. Thus, the embryonic limb contains the necessary components to produce polyamine-derived cytotoxic metabolites, which are present at the time programmed cell death occurs. This leads to the hypothesis that injected melanoma cells are killed incidentally by the mechanism that mediates programmed cell death. |
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Authors:
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R E Parchment; G B Pierce |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cancer research Volume: 49 ISSN: 0008-5472 ISO Abbreviation: Cancer Res. Publication Date: 1989 Dec |
Date Detail:
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Created Date: 1989-12-27 Completed Date: 1989-12-27 Revised Date: 2011-11-02 |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 6680-6 Citation Subset: IM |
Affiliation:
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Department of Pathology, University of Colorado School of Medicine, Denver 80262. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amine Oxidase (Copper-Containing)
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metabolism Animals Cell Survival Cytotoxins / physiology Extremities / embryology* Melanoma, Experimental / pathology* Mice Organ Culture Techniques Oxidoreductases Acting on CH-NH Group Donors / metabolism Polyamines / metabolism* Transforming Growth Factors / physiology Tumor Cells, Cultured |
| Grant Support | |
ID/Acronym/Agency:
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CA 35367/CA/NCI NIH HHS; CA-47369/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cytotoxins; 0/Polyamines; 76057-06-2/Transforming Growth Factors; EC 1.4.3.6/Amine Oxidase (Copper-Containing); EC 1.5.-/Oxidoreductases Acting on CH-NH Group Donors; EC 1.5.3.-/polyamine oxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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