Document Detail


Polyamine oxidation, programmed cell death, and regulation of melanoma in the murine embryonic limb.
MedLine Citation:
PMID:  2510929     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The murine embryonic limb at day 14 of gestation suppresses tumor formation by melanoma cells. Conditioned media of embryonic limbs have been found cytotoxic for B16 melanoma cells. The cytotoxicity is due to the catabolism of polyamines in the limb bud extracts by an amine oxidase in the serum supplement of the culture medium. However, a polyamine oxidase activity, similar to that in adult rat liver, is also detectable in homogenates of embryonic limbs. Thus, the embryonic limb contains the necessary components to produce polyamine-derived cytotoxic metabolites, which are present at the time programmed cell death occurs. This leads to the hypothesis that injected melanoma cells are killed incidentally by the mechanism that mediates programmed cell death.
Authors:
R E Parchment; G B Pierce
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer research     Volume:  49     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1989-12-27     Completed Date:  1989-12-27     Revised Date:  2011-11-02    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  6680-6     Citation Subset:  IM    
Affiliation:
Department of Pathology, University of Colorado School of Medicine, Denver 80262.
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MeSH Terms
Descriptor/Qualifier:
Amine Oxidase (Copper-Containing) / metabolism
Animals
Cell Survival
Cytotoxins / physiology
Extremities / embryology*
Melanoma, Experimental / pathology*
Mice
Organ Culture Techniques
Oxidoreductases Acting on CH-NH Group Donors / metabolism
Polyamines / metabolism*
Transforming Growth Factors / physiology
Tumor Cells, Cultured
Grant Support
ID/Acronym/Agency:
CA 35367/CA/NCI NIH HHS; CA-47369/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Cytotoxins; 0/Polyamines; 76057-06-2/Transforming Growth Factors; EC 1.4.3.6/Amine Oxidase (Copper-Containing); EC 1.5.-/Oxidoreductases Acting on CH-NH Group Donors; EC 1.5.3.-/polyamine oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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