Document Detail

Polyamine oxidation, programmed cell death, and regulation of melanoma in the murine embryonic limb.
MedLine Citation:
PMID:  2510929     Owner:  NLM     Status:  MEDLINE    
The murine embryonic limb at day 14 of gestation suppresses tumor formation by melanoma cells. Conditioned media of embryonic limbs have been found cytotoxic for B16 melanoma cells. The cytotoxicity is due to the catabolism of polyamines in the limb bud extracts by an amine oxidase in the serum supplement of the culture medium. However, a polyamine oxidase activity, similar to that in adult rat liver, is also detectable in homogenates of embryonic limbs. Thus, the embryonic limb contains the necessary components to produce polyamine-derived cytotoxic metabolites, which are present at the time programmed cell death occurs. This leads to the hypothesis that injected melanoma cells are killed incidentally by the mechanism that mediates programmed cell death.
R E Parchment; G B Pierce
Related Documents :
1379889 - Role of vitronectin in embryonic rat endocardial cell migration in vitro.
2510929 - Polyamine oxidation, programmed cell death, and regulation of melanoma in the murine em...
3835779 - Effect of arginine-butyrate on interferon induction by adenovirus.
16861659 - Cj1496c encodes a campylobacter jejuni glycoprotein that influences invasion of human e...
8125199 - Sorting out of cells from different parts and stages of the chick limb bud.
19794819 - Who moves whom during primitive streak formation in the chick embryo.
493869 - Oscillations of granulocytic and megakaryocytic progenitor cell populations in cyclic n...
1256059 - Selective modification of cell surface proteins and thymidine transport in hamster cell...
7649259 - Biosynthesis and apical localization of the urokinase receptor in polarized mdck epithe...
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer research     Volume:  49     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1989-12-27     Completed Date:  1989-12-27     Revised Date:  2011-11-02    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  6680-6     Citation Subset:  IM    
Department of Pathology, University of Colorado School of Medicine, Denver 80262.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amine Oxidase (Copper-Containing) / metabolism
Cell Survival
Cytotoxins / physiology
Extremities / embryology*
Melanoma, Experimental / pathology*
Organ Culture Techniques
Oxidoreductases Acting on CH-NH Group Donors / metabolism
Polyamines / metabolism*
Transforming Growth Factors / physiology
Tumor Cells, Cultured
Grant Support
Reg. No./Substance:
0/Cytotoxins; 0/Polyamines; 76057-06-2/Transforming Growth Factors; EC Oxidase (Copper-Containing); EC 1.5.-/Oxidoreductases Acting on CH-NH Group Donors; EC 1.5.3.-/polyamine oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Modulation of ovarian carcinoma tumor marker CA-125 by gamma-interferon.
Next Document:  Detection of transforming growth factor-alpha messenger RNA in normal and chemically transformed ham...