Document Detail


Polyamine depletion influences drug-induced chromosomal damage.
MedLine Citation:
PMID:  6810463     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Polyamines have been implicated in the intracellular stabilization of DNA. Depletion of intracellular polyamines influences the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea and cis-diamminedichloroplatinum II. By means of the sister chromatid exchange assay, it was found that intracellular polyamine depletion can also alter the induction of chromosomal damage by these cytotoxic agents.
Authors:
P J Tofilon; S M Oredsson; D F Deen; L J Marton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Retracted Publication    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  217     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1982 Sep 
Date Detail:
Created Date:  1982-10-12     Completed Date:  1982-10-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1044-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Carmustine / pharmacology
Chromosomes / drug effects
Cisplatin / pharmacology
DNA / metabolism
Eflornithine
Nucleic Acid Conformation
Ornithine / analogs & derivatives,  pharmacology
Polyamines / metabolism*
Putrescine
Rats
Sister Chromatid Exchange
Spermidine
Spermine
Grant Support
ID/Acronym/Agency:
CA 09215/CA/NCI NIH HHS; CA 13525/CA/NCI NIH HHS; CA 31867/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Polyamines; 110-60-1/Putrescine; 124-20-9/Spermidine; 154-93-8/Carmustine; 15663-27-1/Cisplatin; 70052-12-9/Eflornithine; 7006-33-9/Ornithine; 71-44-3/Spermine; 9007-49-2/DNA
Comments/Corrections
Retraction In:
Milam KM, Horn S, Tofilon PJ, Deen DF, Marton LJ. Science. 1989 May 12;244(4905):631   [PMID:  2655085 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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