| Poly(amidoamine) conjugates containing doxorubicin bound via an acid-sensitive linker. | |
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MedLine Citation:
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PMID: 19016501 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Poly(amidoamine)s with amino pendant groups were prepared by hydrogen-transfer polyaddition of primary and secondary amines to bis-acrylamines. Dansyl cadaverine (DC) doxorubicin (Dox) were bound to the polymers via a cis-aconityl spacer to give conjugates containing 3 microg of DC per mg of polymer and 28 to 35 microg of Dox per mg of polymer. Release of DC and Dox at physiological and acidic pH varied from 0 to 35% over 48 h and was pH dependent. Although the ISA1Dox conjugate (IC(50) = 6 microg Dox x mL(-1)) presented similar toxicity as the parent polymer without Dox, ISA23Dox showed increased toxicity (IC(50) = 10 microg Dox x mL(-1)). These results suggest that ISA23Dox is able to release biologically active Dox in vitro and that this conjugate might be suitable for further development. |
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Authors:
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Nathalie Lavignac; Johanna L Nicholls; Paolo Ferruti; Ruth Duncan |
Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Macromolecular bioscience Volume: 9 ISSN: 1616-5195 ISO Abbreviation: Macromol Biosci Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-05-25 Completed Date: 2009-07-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101135941 Medline TA: Macromol Biosci Country: Germany |
Other Details:
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Languages: eng Pagination: 480-7 Citation Subset: IM |
Affiliation:
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Centre for Polymer Therapeutics, Welsh School of Pharmacy, Redwood Building, Cardiff University, Cardiff, UK. n.lavignac@kent.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibiotics, Antineoplastic / chemistry*, pharmacology Biocompatible Materials / chemistry, pharmacology Cadaverine / analogs & derivatives, chemistry Cell Line, Tumor / drug effects Doxorubicin / chemistry*, pharmacology Drug Carriers / chemistry* Drug Screening Assays, Antitumor Humans Hydrogen-Ion Concentration Materials Testing Mice Molecular Structure Neoplasms / drug therapy Polymers / chemistry* |
| Grant Support | |
ID/Acronym/Agency:
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//Biotechnology and Biological Sciences Research Council |
| Chemical | |
Reg. No./Substance:
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0/Antibiotics, Antineoplastic; 0/Biocompatible Materials; 0/Drug Carriers; 0/Polymers; 10121-91-2/monodansylcadaverine; 23214-92-8/Doxorubicin; 462-94-2/Cadaverine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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