Document Detail


Polyamide amino acids: a new class of RNA ligands.
MedLine Citation:
PMID:  19377666     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This communication introduces a new class of promising RNA ligands, named polyamide amino acids (PAA), which are able to bind a targeted bulged stem-loop RNA fragment (HIV-1 TAR RNA) with micromolar affinities and with specificity comparative to dsDNA and tRNA; both the affinity and the specificity of PAA for TAR depend on their length and on the nature of the amino acid residues.
Authors:
Vanessa Bonnard; Stéphane Azoulay; Audrey Di Giorgio; Nadia Patino
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-06
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  -     ISSN:  1359-7345     ISO Abbreviation:  Chem. Commun. (Camb.)     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-20     Completed Date:  2009-06-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  England    
Other Details:
Languages:  eng     Pagination:  2302-4     Citation Subset:  IM    
Affiliation:
Laboratoire de Chimie des Molécules Bioactives et des Arômes, UMR 6001 CNRS UNSA, Institut de Chimie de Nice, Université de Nice Sophia Antipolis, 06108 Nice Cedex, France.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / chemistry*,  metabolism*
Ligands
Molecular Structure
Nylons / chemical synthesis,  chemistry*,  metabolism*
RNA / chemistry*,  metabolism*
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Ligands; 0/Nylons; 63231-63-0/RNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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