Document Detail


Polyamide amino acids trimers as TAR RNA ligands and anti-HIV agents.
MedLine Citation:
PMID:  20889349     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Based on a split-and-mix strategy, a library of trimeric Polyamide Amino Acids (PAA) incorporating four different amino acids (Lys, Ala, Arg, and Phe) has been prepared. Screening of the batches for HIV TAR RNA binding in a fluorescent assay allowed the identification of several components that interact with TAR RNA at a micromolar concentration, with a good TAR versus tRNA specificity. Some of these compounds compete efficiently with the association of TAR and Tat protein. In cell cultures, these compounds display a moderate antiviral activity, associated nevertheless with some toxicity. Overall, these results confirm that this new family can be a basis for the design of novel RNA targeting drugs.
Authors:
Vanessa Bonnard; Lise Pascale; Stéphane Azoulay; Audrey Di Giorgio; Christine Rogez-Kreuz; Karine Storck; Pascal Clayette; Nadia Patino
Related Documents :
4992319 - Possible inhibitory effect of teichoic acid on bacillus subtilis transfer ribonucleic a...
3733929 - Use of pico-tag methodology in the chemical analysis of peptides with carboxyl-terminal...
11297349 - Synthesis of tetrapeptide p-nitrophenylanilides containing dehydroalanine and dehydroph...
2202949 - Characterization of monoclonal antibodies specific to the activated ras p21 with aspart...
18969349 - Influence of amide linkages on acidity determinations of humic substances testing with ...
15121199 - Fragmentation of protonated ions of peptides containing cysteine, cysteine sulfinic aci...
20729019 - Forensic utility of isotope ratio analysis of the explosive urea nitrate and its precur...
21278279 - Poly-alpha-glutamic acid synthesis using a novel catalytic activity of rimk from escher...
2384159 - Arachidonic acid epoxygenase. stereochemical analysis of the endogenous epoxyeicosatrie...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-07
Journal Detail:
Title:  Bioorganic & medicinal chemistry     Volume:  18     ISSN:  1464-3391     ISO Abbreviation:  Bioorg. Med. Chem.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9413298     Medline TA:  Bioorg Med Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  7432-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Laboratoire de Chimie des Molécules Bioactives et des Arômes, UMR 6001 CNRS UNSA, Institut de Chimie de Nice, Université de Nice Sophia Antipolis, 06108 Nice Cedex, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Fluorescent-tagged sp2-iminosugars with potent ?-glucosidase inhibitory activity.
Next Document:  Long-term results of one-and-a-half ventricle repair in complex cardiac anomalies.