| Polyacetylenic compounds, ACAT inhibitors from the roots of Panax ginseng. | |
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MedLine Citation:
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PMID: 15712998 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acyl-CoA: cholesterol acyltransferase (ACAT), which plays a role in the absorption, storage, and production of cholesterol, has been explored as a potential target for pharmacological intervention of hyperlipidemia and atherosclerotic disease. In our search for ACAT inhibitors from natural sources, the petroleum ether extract of Panax ginseng showed moderate inhibition of ACAT enzyme from rat liver microsomes. Bioactivity-guided fractionations led to the isolation of one new polyacetylenic compound, (9R,10S)-epoxy-16-heptadecene-4, 6-diyne-3-one (1), in addition to the previously reported polyacetylenic compounds 2 and 3. Their chemical structures were elucidated on the basis of spectroscopic evidence (UV, IR, NMR, and MS). The compounds 1, 2, and 3 showed significant ACAT inhibition with IC(50) values of 35, 47, and 21 microM, respectively. |
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Authors:
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Mun-Chual Rho; Hyun Sun Lee; Seung Woong Lee; Jong Sun Chang; Oh Eok Kwon; Mi Yeon Chung; Young Kook Kim |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: 53 ISSN: 0021-8561 ISO Abbreviation: J. Agric. Food Chem. Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-02-16 Completed Date: 2005-03-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: United States |
Other Details:
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Languages: eng Pagination: 919-22 Citation Subset: IM |
Affiliation:
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Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology, 52 Eoundong, Yusong-gu, Taejon 305-333, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylene
/
analogs & derivatives*,
analysis*,
chemistry,
isolation & purification*,
pharmacology Alkynes Animals Diynes Enzyme Inhibitors / chemistry, isolation & purification*, pharmacology Epoxy Compounds / chemistry, isolation & purification*, pharmacology Microsomes, Liver / enzymology Molecular Structure Panax / chemistry* Plant Roots / chemistry* Polyacetylenes Polymers / analysis*, chemistry Rats Sterol O-Acyltransferase / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/(9R,10S)-epoxy-16-heptadecene-4, 6-diyne-3-one; 0/Alkynes; 0/Diynes; 0/Enzyme Inhibitors; 0/Epoxy Compounds; 0/Polymers; 25067-58-7/Polyacetylenes; 74-86-2/Acetylene; EC 2.3.1.26/Sterol O-Acyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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