| Poly(N-isopropylacrylamide) beads synthesis with nanoparticles embedded for the implementation of shrinkable medical microrobots for biomedical applications. | |
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MedLine Citation:
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PMID: 21097054 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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This paper describes the synthesis of thermoresponsive hydrogel bead for the implementation of untethered medical microrobots and other microdevices. These entities will have magnetic nanoparticles embedded, and will be targeted inside the body with an adapted Magnetic Resonance Imaging (MRI) system, and then triggered by the application of an alternating magnetic field for various functions, including but not limited to drug delivery and release. A method is presented here to synthesize PNIPA particles, within alginate mold, which can be dissolved when hydrogel is completely polymerized and particles with diameter around 1mm are synthesized, with possibility of reducing the size with an electrostatic fields. Interesting volume losses has been recorded, depending of the crosslinker concentration. Hydrogel with nanoparticles embedded has also been synthesized, without affecting the polymerization, and with no significant effect on the volume change. Finally, transition temperature has been increase over the body temperature by copolymerization with acrylic acid. |
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Authors:
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Jacinthe Lapointe; Sylvain Martel |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference Volume: 1 ISSN: 1557-170X ISO Abbreviation: Conf Proc IEEE Eng Med Biol Soc Publication Date: 2010 |
Date Detail:
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Created Date: 2010-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101243413 Medline TA: Conf Proc IEEE Eng Med Biol Soc Country: United States |
Other Details:
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Languages: eng Pagination: 3800-3 Citation Subset: IM |
Affiliation:
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NanoRobotics Laboratory, Department of Computer Engineering, Ecole Polytechnique of Montreal, QC, Canada, H3J 1J4. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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