| Poly(D,L-lactide) nanoencapsulation to reduce photoinactivation of a sunscreen agent. | |
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MedLine Citation:
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PMID: 18452438 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The use of sunscreens is the 'gold standard' for protecting the skin from ultraviolet light. Octyl methoxycinnamate (OMC) is one of the most widely used UVB filter but it can act as a sensitizer or photoallergen. When exposed to sunlight, OMC can change from the primary trans-form to cis-form and the isomerization, not reversible, conducts to a reduction of the UVB filtering efficiency because the trans-form has a higher extinction coefficient. Photostability is the most important characteristic of effective sunscreens and it can be influenced by formulation ingredients and by applying technological strategies. In this work, photostability experiments, performed on emulsion-gels containing different percentages of OMC free or loaded in poly(D,L-lactide) nanoparticles, were carried out. The presence of a polymeric envelop may act to protect the active ingredient. In this study, the influence of poly(D,L-lactide) matrices on the photochemical stability of the sunscreen agent was investigated. As highlighted in this study, free OMC in different formulations has different photoisomerization degree. Moreover, a dissimilar behaviour was observed by studying different sunscreen concentrations in the same cosmetic formulation. Photostability results show a significant reduction in photoisomerization degree for formulations containing sunscreen loaded in nanoparticles, highlighting that the encapsulation is a suitable strategy to improve OMC photostability. Moreover, sun protection factor (SPF) results show that the UVB filter protective power is also maintained after encapsulation. |
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Authors:
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M Vettor; P Perugini; S Scalia; B Conti; I Genta; T Modena; F Pavanetto |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of cosmetic science Volume: 30 ISSN: 1468-2494 ISO Abbreviation: Int J Cosmet Sci Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-02 Completed Date: 2008-06-20 Revised Date: 2008-09-18 |
Medline Journal Info:
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Nlm Unique ID: 8007161 Medline TA: Int J Cosmet Sci Country: England |
Other Details:
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Languages: eng Pagination: 219-27 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Chemistry, School of Pharmacy, University of Pavia, 27100 Pavia, Italy. manuela.vettor@unipv.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cinnamates
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chemistry*,
radiation effects Drug Stability Emulsions / chemistry Isomerism Nanoparticles / chemistry* Polyesters / chemistry* Spectrophotometry, Ultraviolet Sunscreening Agents / chemistry*, radiation effects Ultraviolet Rays |
| Chemical | |
Reg. No./Substance:
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0/Cinnamates; 0/Emulsions; 0/Polyesters; 0/Sunscreening Agents; 0/octylmethoxycinnamate; 26969-66-4/poly(lactide) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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