| Poly(D,L-lactic acid)-block-(ligand-tethered poly(ethylene glycol)) copolymers as surface additives for promoting chondrocyte attachment and growth. | |
| | |
MedLine Citation:
|
PMID: 16130143 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The poly(D,L-lactic acid)-block-(ligand-tethered poly(ethylene glycol)) copolymer was explored to engineer poly(D,L-lactic acid) (PLA) material to promote chondrocyte attachment and growth. The poly(D,L-lactic acid)-block-poly(ethylene glycol) copolymer (PLE) was synthesized by a coupling reaction between PLA and poly(ethylene glycol) (PEG) (M(n) 1000, 2000, and 4000 respectively), with the use of 4,4'-methylenediphenyl diisocyanate (MDI). Then the PLE was activated by methyl sulfonyl chloride and the amino acids or arginine-glycine-aspartic acid tripeptide (RGD) was attached, which was verified by the ninhydrin-UV method. The modified PLA films were simply prepared by blending PLA with PLE derivatives. ATR-FTIR, XPS, contact angle, and AFM results clearly showed that the PEG chain stably enriched on the surface of PLE-modified PLA films. The chondrocyte cytocompatibility test showed the modified PLA films could significantly improve chondrocyte attachment and proliferation. |
| | |
Authors:
|
Guanhua Yu; Jian Ji; Huiguang Zhu; Jiacong Shen |
Related Documents
:
|
16260683 - Tissue restoration after resorption of polyglycolide and poly-laevo-lactic acid screws. 15132453 - Efficacy of using self-etching primer with a 4-meta/mma-tbb resin cement in bonding ort... 2899723 - Defective bile acid amidation: predicted features of a new inborn error of metabolism. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of biomedical materials research. Part B, Applied biomaterials Volume: 76 ISSN: 1552-4973 ISO Abbreviation: J. Biomed. Mater. Res. Part B Appl. Biomater. Publication Date: 2006 Jan |
Date Detail:
|
Created Date: 2005-12-19 Completed Date: 2006-04-24 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 101234238 Medline TA: J Biomed Mater Res B Appl Biomater Country: United States |
Other Details:
|
Languages: eng Pagination: 64-75 Citation Subset: IM |
Affiliation:
|
Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cell Adhesion
/
drug effects* Cell Division / drug effects Chondrocytes / cytology, drug effects*, ultrastructure Microscopy, Confocal Microscopy, Electron, Scanning Polyesters / chemistry* Polyethylene Glycols / chemistry* Spectroscopy, Fourier Transform Infrared |
| Chemical | |
Reg. No./Substance:
|
0/Polyesters; 0/Polyethylene Glycols; 26969-66-4/poly(lactide) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Regulation of pulmonary arterial myosin phosphatase activity in neonatal circulatory transition and ...
Next Document: Strength and fatigue performance versus filler fraction of different types of direct dental restorat...