| Poly(ADP-ribose) polymerase: a new therapeutic target? | |
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MedLine Citation:
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PMID: 18443476 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: To overview the emerging data in the literature showing the role of poly(ADP-ribose) polymerase (PARP) in the pathogenesis of critical illness. RECENT FINDINGS: PARP, an abundant nuclear enzyme involved in DNA repair and transcriptional regulation, is now recognized as a key regulator of cell survival and cell death in response to noxious stimuli in various forms of cardiovascular collapse. PARP becomes activated in response to oxidative DNA damage and depletes cellular energy pools, thus leading to cellular dysfunction in various tissues. The activation of PARP may also induce various cell death processes, and promotes an inflammatory response. In circulatory shock PARP plays a crucial role both in the development of early cardiovascular dysfunction and in the delayed systemic inflammatory response syndrome with associated multiple organ failure. Inhibition of PARP activity is protective in various models of circulatory shock. SUMMARY: A solid body of literature supports the view that PARP is an important target for therapeutic intervention in critical illness. |
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Authors:
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Domokos Gerö; Csaba Szabó |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current opinion in anaesthesiology Volume: 21 ISSN: 0952-7907 ISO Abbreviation: Curr Opin Anaesthesiol Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-04-29 Completed Date: 2008-05-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8813436 Medline TA: Curr Opin Anaesthesiol Country: United States |
Other Details:
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Languages: eng Pagination: 111-21 Citation Subset: IM |
Affiliation:
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CellScreen Applied Research Center, Semmelweis University Medical School, Budapest, Hungary. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Critical Illness Endothelium, Vascular / physiopathology Humans Intestinal Mucosa / metabolism Liver Diseases / etiology Lung / metabolism Multiple Organ Failure / etiology Permeability Poly(ADP-ribose) Polymerases / antagonists & inhibitors*, physiology Shock, Septic / drug therapy*, physiopathology Vasoconstriction |
| Chemical | |
Reg. No./Substance:
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EC 2.4.2.30/Poly(ADP-ribose) Polymerases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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