| Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding. | |
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MedLine Citation:
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PMID: 20832105 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Circadian clocks in peripheral organs are tightly coupled to cellular metabolism and are readily entrained by feeding-fasting cycles. However, the molecular mechanisms involved are largely unknown. Here we show that in liver the activity of PARP-1, an NAD(+)-dependent ADP-ribosyltransferase, oscillates in a daily manner and is regulated by feeding. We provide biochemical evidence that PARP-1 binds and poly(ADP-ribosyl)ates CLOCK at the beginning of the light phase. The loss of PARP-1 enhances the binding of CLOCK-BMAL1 to DNA and leads to a phase-shift of the interaction of CLOCK-BMAL1 with PER and CRY repressor proteins. As a consequence, CLOCK-BMAL1-dependent gene expression is altered in PARP-1-deficient mice, in particular in response to changes in feeding times. Our results show that Parp-1 knockout mice exhibit impaired food entrainment of peripheral circadian clocks and support a role for PARP-1 in connecting feeding with the mammalian timing system. |
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Authors:
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Gad Asher; Hans Reinke; Matthias Altmeyer; Maria Gutierrez-Arcelus; Michael O Hottiger; Ueli Schibler |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-09 |
Journal Detail:
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Title: Cell Volume: 142 ISSN: 1097-4172 ISO Abbreviation: Cell Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-20 Completed Date: 2010-10-18 Revised Date: 2010-10-28 |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: United States |
Other Details:
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Languages: eng Pagination: 943-53 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Molecular Biology, University of Geneva, 1211 Geneva 4, Switzerland. gad.asher@unige.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Clocks* Circadian Rhythm* Circadian Rhythm Signaling Peptides and Proteins / metabolism Feeding Behavior* Liver / metabolism Mice Mice, Knockout Poly(ADP-ribose) Polymerases / genetics, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Circadian Rhythm Signaling Peptides and Proteins; EC 2.4.2.30/Poly(ADP-ribose) Polymerases; EC 2.4.2.30/poly(ADP-ribose)polymerase-1, mouse |
| Comments/Corrections | |
Comment In:
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Cell. 2010 Sep 17;142(6):841-3
[PMID:
20850006
]
Nat Rev Mol Cell Biol. 2010 Nov;11(11):754-5 [PMID: 20944668 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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